Ursolic acid induces cell death and modulates autophagy through JNK pathway in apoptosis-resistant colorectal cancer cells
Colorectal carcinomas (CRCs) with P53 mutations have been shown to be resistant to
chemotherapy with 5-fluorouracil (5-FU), the most widely used chemotherapeutic drug for …
chemotherapy with 5-fluorouracil (5-FU), the most widely used chemotherapeutic drug for …
Berberine: A potential adjunct for the treatment of gastrointestinal cancers?
AR Hesari, F Ghasemi, AFG Cicero… - Journal of cellular …, 2018 - Wiley Online Library
Gastrointestinal cancers are among the most prevalent cancers in the general population.
Despite effective early diagnostics and intervention, the gastrointestinal cancer‐related …
Despite effective early diagnostics and intervention, the gastrointestinal cancer‐related …
[HTML][HTML] Capsaicin and sorafenib combination treatment exerts synergistic anti‑hepatocellular carcinoma activity by suppressing EGFR and PI3K/Akt/mTOR signaling
N Dai, R Ye, Q He, P Guo, H Chen… - Oncology …, 2018 - spandidos-publications.com
Abstract Capsaicin (8‑methyl N‑vanillyl‑6 nonenamide) is a natural plant extract that has
antitumor properties and induces apoptosis and autophagy in various types of malignancies …
antitumor properties and induces apoptosis and autophagy in various types of malignancies …
Mechanisms by which thiazolidinediones induce anti-cancer effects in cancers in digestive organs
T Okumura - Journal of gastroenterology, 2010 - Springer
Increasing evidence suggests that thiazolidinediones (TZDs) could have a therapeutic
potential for patients with cancers. Here, the evidence on the mechanisms by which TZDs …
potential for patients with cancers. Here, the evidence on the mechanisms by which TZDs …
Butyrate induced Caco-2 cell apoptosis is mediated via the mitochondrial pathway
FM Ruemmele, S Schwartz, EG Seidman, S Dionne… - Gut, 2003 - gut.bmj.com
Background: During the process of tumorigenesis most colon cancer cells acquire
resistance to apoptosis. The short chain fatty acid butyrate is well established as an …
resistance to apoptosis. The short chain fatty acid butyrate is well established as an …
Bromelain: biochemistry, pharmacology and medical use
HR Maurer - Cellular and Molecular Life Sciences CMLS, 2001 - Springer
Bromelain is a crude extract from the pineapple that contains, among other components,
various closely related proteinases, demonstrating, in vitro and in vivo, antiedematous …
various closely related proteinases, demonstrating, in vitro and in vivo, antiedematous …
[HTML][HTML] 7-Acetylsinumaximol B induces apoptosis and autophagy in human gastric carcinoma cells through mitochondria dysfunction and activation of the PERK …
The 7-Acetylsinumaximol B (7-AB), a bioactive cembranoid, was originally discovered from
aquaculture soft coral Sinularia sandensis. The current study investigated the anti …
aquaculture soft coral Sinularia sandensis. The current study investigated the anti …
Bufalin inhibits HCT116 colon cancer cells and its orthotopic xenograft tumor in mice model through genes related to apoptotic and PTEN/AKT pathways
J Wang, C Chen, S Wang, Y Zhang… - Gastroenterology …, 2015 - Wiley Online Library
Aims. To investigate the anticolorectal cancer (CRC) effects of Bufalin, a bioactive
polyhydroxysteroid from Venenum Bufonis, using HCT116 human CRC cell and an …
polyhydroxysteroid from Venenum Bufonis, using HCT116 human CRC cell and an …
[HTML][HTML] Combination of rapamycin and garlic-derived S-allylmercaptocysteine induces colon cancer cell apoptosis and suppresses tumor growth in xenograft nude …
S Li, G Yang, X Zhu, L Cheng, Y Sun… - Oncology …, 2017 - spandidos-publications.com
The natural plant-derived product S-allylmercaptocysteine (SAMC) has been studied in
cancer therapy as a single and combination chemotherapeutic agent. The present study was …
cancer therapy as a single and combination chemotherapeutic agent. The present study was …
TanshinoneáIIA induces growth inhibition and apoptosis in gastric cancer in vitro and in vivo
J Chen, DY Shi, SL Liu, L Zhong - Oncology reports, 2012 - spandidos-publications.com
As a phytochemical derived from the roots of Salvia miltiorrhiza Bunge, TanshinoneáIIA has
been reported to possess anti-inflammatory and antioxidant activity. Studies in breast, colon …
been reported to possess anti-inflammatory and antioxidant activity. Studies in breast, colon …