[HTML][HTML] Capsaicin and sorafenib combination treatment exerts synergistic anti‑hepatocellular carcinoma activity by suppressing EGFR and PI3K/Akt/mTOR signaling

N Dai, R Ye, Q He, P Guo, H Chen… - Oncology …, 2018 - spandidos-publications.com
Abstract Capsaicin (8‑methyl N‑vanillyl‑6 nonenamide) is a natural plant extract that has
antitumor properties and induces apoptosis and autophagy in various types of malignancies …

Bufalin inhibits HCT116 colon cancer cells and its orthotopic xenograft tumor in mice model through genes related to apoptotic and PTEN/AKT pathways

J Wang, C Chen, S Wang, Y Zhang… - Gastroenterology …, 2015 - Wiley Online Library
Aims. To investigate the anticolorectal cancer (CRC) effects of Bufalin, a bioactive
polyhydroxysteroid from Venenum Bufonis, using HCT116 human CRC cell and an …

[HTML][HTML] Combination of rapamycin and garlic-derived S-allylmercaptocysteine induces colon cancer cell apoptosis and suppresses tumor growth in xenograft nude …

S Li, G Yang, X Zhu, L Cheng, Y Sun… - Oncology …, 2017 - spandidos-publications.com
The natural plant-derived product S-allylmercaptocysteine (SAMC) has been studied in
cancer therapy as a single and combination chemotherapeutic agent. The present study was …

[HTML][HTML] Growth inhibition and apoptosis induction of Sulindac on Human gastric cancer cells

YL Wu, B Sun, XJ Zhang, SN Wang, HY He… - World Journal of …, 2001 - ncbi.nlm.nih.gov
AIM: To evaluate the effects of sulindac in inducing growth inhibition and apoptosis of
human gastric cancer cells in comparison with human hepatocellular carcinoma (HCC) …

[HTML][HTML] 7-Acetylsinumaximol B induces apoptosis and autophagy in human gastric carcinoma cells through mitochondria dysfunction and activation of the PERK …

TC Tsai, KH Lai, JH Su, YJ Wu, JH Sheu - Marine drugs, 2018 - mdpi.com
The 7-Acetylsinumaximol B (7-AB), a bioactive cembranoid, was originally discovered from
aquaculture soft coral Sinularia sandensis. The current study investigated the anti …

Tributyrin, an oral butyrate analogue, induces apoptosis through the activation of caspase-3

KO Clarke, R Feinman, LE Harrison - Cancer letters, 2001 - Elsevier
The purpose of this study was to investigate the anti-proliferative and pro-apoptotic effects of
the butyrate analogues, tributyrin (TB) and phenylbutyrate (PB), in a colon cancer model. We …

[HTML][HTML] Opposing effects of butyrate and bile acids on apoptosis of human colon adenoma cells: differential activation of PKC and MAP kinases

L McMillan, SK Butcher, J Pongracz, JM Lord - British journal of cancer, 2003 - nature.com
Butyrate, produced in the colon by fermentation of dietary fibre, induces apoptosis in colon
adenoma and cancer cell lines, which may contribute to protection against colorectal cancer …

Sodium butyrate modulates cell cycle‐related proteins in HT29 human colonic adenocarcinoma cells

D Coradini, C Pellizzaro, D Marimpietri… - Cell …, 2000 - Wiley Online Library
Sodium butyrate (NaB), a product of colonic fermentation of dietary fibre, has been shown to
inhibit cell proliferation by blocking cells in the G0/G1 phase of the cell cycle through a …

Antitumor activity in colorectal cancer induced by hinokiflavone

J Zhou, R Zhao, T Ye, S Yang, Y Li… - Journal of …, 2019 - Wiley Online Library
Abstract Background and Aim Colorectal cancer is one of the most common malignant
disease worldwide with highly metastatic potential. Identification of effective therapeutic …

Gambogic acid induced oxidative stress dependent caspase activation regulates both apoptosis and autophagy by targeting various key molecules (NF-κB, Beclin-1 …

M Ishaq, MA Khan, K Sharma, G Sharma… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Background Gambogic acid is a potent anticancer agent and has been found effective
against various types of cancer cells. The present study was addressed to explore the …