The developmental pathways of long-lived memory CD8 T cells and the lineage relationship
between memory T cell subsets remain controversial. Although some studies indicate the …

Memory CD8+ T cells are an important component of the adaptive immune response against
many infections, and understanding how Ag-specific memory CD8+ T cells are generated …

During an infection, T cells can differentiate into multiple types of effector and memory T
cells, which help to mediate pathogen clearance and provide long-term protective immunity …

For acute self-limiting infections a vaccine is successful if it elicits memory at least as good
as the natural experience; however, for persistent and chronic infections such as HIV …

Immunological memory provides rapid protection to pathogens previously encountered
through infection or vaccination. CD 4 T‐cells play a central role in all adaptive immune …

Following infection or vaccination, naïve CD8 T cells that receive the appropriate integration
of antigenic, co‐stimulatory and inflammatory signals undergo a programmed series of …

T cell memory is a cornerstone of protective immunity, and is the key element in successful
vaccination. Upon encountering the relevant pathogen, memory T cells are thought to initiate …

Memory for antigen is a defining feature of adaptive immunity. Antigen-specific lymphocyte
populations show an increase in number and function after antigen encounter and more …

Adaptive immunity is characterized by the ability to form long-lived immunological memory.
Upon re-exposure to antigen, memory T cells respond more rapidly and robustly than naïve …

How and when memory T cells form during an immune response are long-standing
questions. To better understand memory CD8 T cell development, a time course of gene …