Recent studies suggest that memory T-cell differentiation continues for weeks or months
following antigen clearance, although commitment to the memory lineage occurs during the …

To design successful vaccines for chronic diseases, an understanding of memory CD8+ T
cell responses to persistent antigen restimulation is critical. However, most studies …

The developmental requirements for immunological memory, a central feature of adaptive
immune responses, is largely obscure. We show that as naive CD8 T cells undergo …

In response to acute infections or vaccines, naive antigen‐specific CD8+ T cells proliferate
and differentiate into effector cytotoxic lymphocytes that acquire the ability to kill infected …

Through genetic recombination, the adaptive immune system generates a diverse T cell
repertoire allowing recognition of a vast spectrum of foreign antigens. Any given CD8+ T cell …

Memory CD8 T cells are an important component of protective immunity against viral
infections, and understanding their development will aid in the design of optimal vaccines …

Of the many dendritic cell (DC) subsets, DCs expressing the monomorphic coreceptor CD8
α-chain (CD8α) are localized permanently in lymphoid organs, whereas' tissue-derived DCs' …

The formation of memory CD8 T cells is an important goal of vaccination. However, although
widespread use of booster immunizations in humans generates secondary and tertiary CD8 …

After infection, many factors coordinate the population expansion and differentiation of CD8+
effector and memory T cells. Using data of unparalleled breadth from the Immunological …

CD8+ T cells (also called cytotoxic T lymphocytes) play a major role in protective immunity
against many infectious pathogens and can eradicate malignant cells. The path from naive …