An important question in memory development is understanding the differences between
effector CD8 T cells that die versus effector cells that survive and give rise to memory cells …

The induction of adaptive immunological memory, mediated by T and B cells, plays an
important role in protective immunity to pathogens induced by previous infections or …

Summary Differential interleukin-2 (IL-2) signaling and production are associated with
disparate effector and memory fates. Whether the IL-2 signals perceived by CD8 T cells …

In the course of an immune response to an infectious microbe, pathogen-specific naïve
CD4+ T cells proliferate extensively and differentiate into effector cells. Most of these cells …

Recent work shows that after stimulation with antigen, CD4+ and CD8+ T cells embark on a
programme of proliferation that is closely linked with the acquisition of effector functions and …

Immunologic memory reflects the ability of a host to more effectively respond to a re-
encounter with a particular pathogen than the first encounter, and when a vaccine mimics …

Memory CD8+ T cells were originally thought to exist as two populations (effector and
central memory). In recent years, a third population called resident memory T cells has been …

After infection, most antigen-specific memory T cells reside in nonlymphoid tissues. Tissue-
specific programming during priming leads to directed migration of T cells to the appropriate …

Conventional CD4+ T cells are composed of naïve, pathogen-specific memory, and
pathogen-independent memory-phenotype (MP) cells under steady state. Naïve and …

Many studies have examined pathways controlling effector T cell differentiation, but less is
known about the fate of individual CD8+ T cells during infection. Here, we examine the …