The impact of blood on liver metabolite profiling–a combined metabolomic and proteomic approach

S Ly‐Verdú, A Schaefer, M Kahle… - Biomedical …, 2014 - Wiley Online Library
Metabolomics has entered the well‐established omic sciences as it is an indispensable
information resource to achieve a global picture of biological systems. The aim of the …

[HTML][HTML] Comparative targeted metabolomic profiles of porcine plasma and serum

S Bovo, G Schiavo, G Galimberti, F Fanelli, F Bertolini… - animal, 2023 - Elsevier
Metabolomics has been used to characterise many biological matrices and obtain detailed
pictures of biological systems based on many metabolites. Plasma and serum are two blood …

Systematic evaluation of serum and plasma collection on the endogenous metabolome

Z Zhou, Y Chen, J He, J Xu, R Zhang, Y Mao, Z Abliz - Bioanalysis, 2017 - Taylor & Francis
Aim: In metabolomics research, the use of different blood collection methods may influence
endogenous metabolites. Materials & methods: Ultra HPLC coupled with MS/MS was …

Serum UPLC-MS/MS metabolic profiling in an experimental model for acute-liver injury reveals potential biomarkers for hepatotoxicity

E Gonzalez, S van Liempd, J Conde-Vancells… - Metabolomics, 2012 - Springer
A key interest in clinical diagnosis and pharmaceutical industry is to have a repertoire of
noninvasive biomarkers to—individually or in combination—be able to infer or predict the …

[HTML][HTML] Metabolic profiling of body fluids and multivariate data analysis

JP Trezzi, C Jäger, S Galozzi, K Barkovits, K Marcus… - MethodsX, 2017 - Elsevier
Metabolome analyses of body fluids are challenging due pre-analytical variations, such as
pre-processing delay and temperature, and constant dynamical changes of biochemical …

Joint MS‐based platforms for comprehensive comparison of rat plasma and serum metabolic profiling

Z Lin, Z Zhang, H Lu, Y Jin, L Yi… - Biomedical …, 2014 - Wiley Online Library
Metabolomics is a rapidly growing field in the comprehensive understanding of cellular and
organism‐specific responses associated with perturbations induced by medicines …

Procedure for tissue sample preparation and metabolite extraction for high-throughput targeted metabolomics

W Römisch-Margl, C Prehn, R Bogumil, C Röhring… - Metabolomics, 2012 - Springer
Reproducible quantification of metabolites in tissue samples is of high importance for
characterization of animal models and identification of metabolic changes that occur in …

Differences in metabolite profiles caused by pre-analytical blood processing procedures

S Nishiumi, M Suzuki, T Kobayashi… - Journal of bioscience and …, 2018 - Elsevier
Recently, the use of metabolomic analysis of human serum and plasma for biomarker
discovery and disease diagnosis in clinical studies has been increasing. The feasibility of …

[HTML][HTML] Important considerations for sample collection in metabolomics studies with a special focus on applications to liver functions

L Smith, J Villaret-Cazadamont, SP Claus, C Canlet… - Metabolites, 2020 - mdpi.com
Metabolomics has found numerous applications in the study of liver metabolism in health
and disease. Metabolomics studies can be conducted in a variety of biological matrices …

[HTML][HTML] Impact of anesthesia and euthanasia on metabolomics of mammalian tissues: studies in a C57BL/6J mouse model

KA Overmyer, C Thonusin, NR Qi, CF Burant… - PloS one, 2015 - journals.plos.org
A critical application of metabolomics is the evaluation of tissues, which are often the primary
sites of metabolic dysregulation in disease. Laboratory rodents have been widely used for …