Background Cardiovascular disease (CVD) and its most common manifestations–including
coronary heart disease (CHD), stroke, heart failure (HF), and atrial fibrillation (AF)–are major …

Rationale: Genome-wide association studies have identified a large number of common
variants (single-nucleotide polymorphisms) associated with atrial fibrillation (AF). These …

Atrial fibrillation (AF) is the most common cardiac rhythm disorder and the prevalence is
increasing. The disease confers an increased risk of severe complications such as heart …

Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous studies have
identified several genetic loci associated with typical AF. We sought to identify common …

Background—Prior transcriptional studies of atrial fibrillation (AF) have been limited to
specific transcripts, animal models, chronic AF, right atria, or small samples. We sought to …

Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting 1–2% of the general
population. A number of studies have demonstrated that AF, and in particular lone AF, has a …

Background—The genetic background of atrial fibrillation (AF) in whites and African
Americans is largely unknown. Genes in cardiovascular pathways have not been …

tial (Figure 1) and may be less reliant on currents involved in the late phases of
repolarization. 10 A number of ion channels that have a modest effect or that are closed …

Atrial fibrillation (AF) is the most common cardiac rhythm abnormality and represents a major
burden, both to patients and to health-care systems. In recent years, increasing evidence …

Identifying upstream strategies targeting molecular pathways that are common to fibrosis
and electrical remodeling leading to atrial fibrillation perpetuation is highly desirable. This …