Inactivity and skeletal muscle metabolism: a vicious cycle in old age

E Rezuş, A Burlui, A Cardoneanu, C Rezuş… - International journal of …, 2020 - mdpi.com
Aging is an inevitable and gradually progressive process affecting all organs and systems.
The musculoskeletal system makes no exception, elderly exhibit an increased risk of …

[HTML][HTML] Skeletal muscle aging: influence of oxidative stress and physical exercise

MJ Gomes, PF Martinez, LU Pagan, RL Damatto… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Skeletal muscle abnormalities are responsible for significant disability in the elderly.
Sarcopenia is the main alteration occurring during senescence and a key public health …

Prevalence and mechanisms of skeletal muscle atrophy in metabolic conditions

L Jun, M Robinson, T Geetha, TL Broderick… - International Journal of …, 2023 - mdpi.com
Skeletal muscle atrophy is prevalent in a myriad of pathological conditions, such as
diabetes, denervation, long-term immobility, malnutrition, sarcopenia, obesity, Alzheimer's …

Role of age-related mitochondrial dysfunction in sarcopenia

E Ferri, E Marzetti, R Calvani, A Picca, M Cesari… - International journal of …, 2020 - mdpi.com
Skeletal muscle aging is associated with a significant loss of skeletal muscle strength and
power (ie, dynapenia), muscle mass and quality of life, a phenomenon known as …

Determinants of muscle and bone aging

E Curtis, A Litwic, C Cooper… - Journal of cellular …, 2015 - Wiley Online Library
Loss of bone and muscle with advancing age represent a huge threat to loss of
independence in later life. Osteoporosis represents a major public health problem through …

Loss of muscle strength during aging studied at the gene level

G Goldspink - Rejuvenation research, 2007 - liebertpub.com
Age-related muscle wasting and increased frailty is a major socioeconomic as well as a
major medical problem. In our quest to extend the quality of life it is important to increase the …

Post‐translational regulation of muscle growth, muscle aging and sarcopenia

Q Zhong, K Zheng, W Li, K An, Y Liu… - Journal of Cachexia …, 2023 - Wiley Online Library
Abstract Skeletal muscle makes up 30–40% of the total body mass. It is of great significance
in maintaining digestion, inhaling and exhaling, sustaining body posture, exercising …

Mitochondrial and skeletal muscle health with advancing age

AR Konopka, KS Nair - Molecular and cellular endocrinology, 2013 - Elsevier
With increasing age there is a temporal relationship between the decline of mitochondrial
and skeletal muscle volume, quality and function (ie, health). Reduced mitochondrial mRNA …

Molecular mechanisms of muscle fatigue

D Constantin-Teodosiu, D Constantin - International journal of molecular …, 2021 - mdpi.com
Muscle fatigue (MF) declines the capacity of muscles to complete a task over time at a
constant load. MF is usually short-lasting, reversible, and is experienced as a feeling of …

Frailty and muscle metabolism dysregulation in the elderly

WJ Evans, G Paolisso, AM Abbatecola, A Corsonello… - Biogerontology, 2010 - Springer
The frailty syndrome is increasingly recognized by geriatricians to identify elders at an
extreme risk of adverse health outcomes. The physiological changes that result in frailty are …