Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinib
K Taniguchi, J Okami, K Kodama… - Cancer …, 2008 - Wiley Online Library
Somatic mutations introduced into the epidermal growth factor receptor (EGFR) gene in non‐
small‐cell lung cancer (NSCLC) are important factors to determine therapeutic responses to …
small‐cell lung cancer (NSCLC) are important factors to determine therapeutic responses to …
Complex mutation patterns of epidermal growth factor receptor gene associated with variable responses to gefitinib treatment in patients with non-small cell lung …
MH Hsieh, YF Fang, WC Chang, HP Kuo, SY Lin… - Lung Cancer, 2006 - Elsevier
Mutational analysis was performed in the kinase domain (exons 18–21) of the EGFR gene
on tumor tissues of 65 non-small cell lung cancer (NSCLC) patients who had received …
on tumor tissues of 65 non-small cell lung cancer (NSCLC) patients who had received …
High frequency of epidermal growth factor receptor mutations with complex patterns in non–small cell lung cancers related to gefitinib responsiveness in Taiwan
SF Huang, HP Liu, LH Li, YC Ku, YN Fu, HY Tsai… - Clinical Cancer …, 2004 - AACR
Purpose: Epidermal growth factor receptor (EGFR) mutations related to gefitinib
responsiveness in non–small cell lung cancer have been found recently. Detection of EGFR …
responsiveness in non–small cell lung cancer have been found recently. Detection of EGFR …
Epidermal growth factor receptor mutations and gene amplification in non–small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials
DW Bell, TJ Lynch, SM Haserlat, PL Harris… - Journal of Clinical …, 2005 - ascopubs.org
Purpose Most cases of non–small-cell lung cancer (NSCLC) with dramatic responses to
gefitinib have specific activating mutations in the epidermal growth factor receptor (EGFR) …
gefitinib have specific activating mutations in the epidermal growth factor receptor (EGFR) …
Relative Abundance of EGFR Mutations Predicts Benefit From Gefitinib Treatment for Advanced Non–Small-Cell Lung Cancer
Q Zhou, XC Zhang, ZH Chen, XL Yin… - Journal of clinical …, 2011 - ascopubs.org
Purpose Our aim was to determine whether abundance of epidermal growth factor receptor
(EGFR) mutations in tumors predicts benefit from treatment with EGFR–tyrosine kinase …
(EGFR) mutations in tumors predicts benefit from treatment with EGFR–tyrosine kinase …
Detection of epidermal growth factor receptor mutations in serum as a predictor of the response to gefitinib in patients with non–small-cell lung cancer
H Kimura, K Kasahara, M Kawaishi, H Kunitoh… - Clinical Cancer …, 2006 - AACR
Cases of non–small-cell lung cancer (NSCLC) carrying the somatic mutation of epidermal
growth factor receptor (EGFR) have been shown to be hyperresponsive to the EGFR …
growth factor receptor (EGFR) have been shown to be hyperresponsive to the EGFR …
Mutation in the tyrosine kinase domain of epidermal growth factor receptor is a predictive and prognostic factor for gefitinib treatment in patients with non–small cell …
TY Chou, CH Chiu, LH Li, CY Hsiao, CY Tzen… - Clinical cancer …, 2005 - AACR
Purpose: Mutations in epidermal growth factor receptor (EGFR) can be used to predict the
tumor response of patients receiving gefitinib for non–small cell lung cancer (NSCLC). We …
tumor response of patients receiving gefitinib for non–small cell lung cancer (NSCLC). We …
The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non–small cell lung cancers
M Tokumo, S Toyooka, K Kiura, H Shigematsu… - Clinical cancer …, 2005 - AACR
Purpose: Recent studies reported that clinical responsiveness to gefitinib was associated
with somatic mutation of epidermal growth factor receptor (EGFR) gene in non–small cell …
with somatic mutation of epidermal growth factor receptor (EGFR) gene in non–small cell …
EGFR Mutation Heterogeneity and the Mixed Response to EGFR Tyrosine Kinase Inhibitors of Lung Adenocarcinomas
ZY Chen, WZ Zhong, XC Zhang, J Su, XN Yang… - The …, 2012 - academic.oup.com
Background. Non-small cell lung cancer patients with epidermal growth factor receptor
(EGFR) mutations have mixed responses to tyrosine kinase inhibitors (TKIs). Intertumor …
(EGFR) mutations have mixed responses to tyrosine kinase inhibitors (TKIs). Intertumor …
Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay
K Endo, A Konishi, H Sasaki, M Takada, H Tanaka… - Lung Cancer, 2005 - Elsevier
Epidermal growth factor receptor (EGFR) gene mutations have been found in a subset of
non-small cell lung cancer (NSCLC) with good clinical response to gefitinib therapy. A quick …
non-small cell lung cancer (NSCLC) with good clinical response to gefitinib therapy. A quick …
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