Neutral lipids induce critical behavior in interfacial monolayers of pulmonary surfactant

BM Discher, KM Maloney, DW Grainger, CA Sousa… - Biochemistry, 1999 - ACS Publications
We have shown previously that lateral compression of pulmonary surfactant monolayers
initially induces separation of two phases but that these remix when the films become more …

[PDF][PDF] Discrepancy between phase behavior of lung surfactant phospholipids and the classical model of surfactant function

B Piknova, WR Schief, V Vogel, BM Discher, SB Hall - Biophysical journal, 2001 - cell.com
The studies reported here used fluorescence microscopy and Brewster angle microscopy to
test the classical model of how pulmonary surfactant forms films that are metastable at high …

[HTML][HTML] Phase separation in monolayers of pulmonary surfactant phospholipids at the air–water interface: composition and structure

BM Discher, WR Schief, V Vogel, SB Hall - Biophysical journal, 1999 - cell.com
The phase behavior of monolayers containing the complete set of purified phospholipids
(PPL) obtained from calf surfactant was investigated as a model for understanding the phase …

[PDF][PDF] Lateral phase separation in interfacial films of pulmonary surfactant

BM Discher, KM Maloney, WR Schief, DW Grainger… - Biophysical journal, 1996 - cell.com
To determine if lateral phase separation occurs in films of pulmonary surfactant, we used
epifluorescence microscopy and Brewster angle microscopy (BAM) to study spread films of …

Effect of neutral lipids on coexisting phases in monolayers of pulmonary surfactant

BM Discher, KM Maloney, DW Grainger, SB Hall - Biophysical chemistry, 2002 - Elsevier
We previously established that compression of monolayers containing the lipids in
pulmonary surfactant, with or without the surfactant proteins, initially leads to phase …

Segregated ordered lipid phases and protein-promoted membrane cohesivity are required for pulmonary surfactant films to stabilize and protect the respiratory surface

JB de la Serna, R Vargas, V Picardi, A Cruz… - Faraday …, 2013 - pubs.rsc.org
Pulmonary surfactant is a lipid–protein complex essential to stabilize alveoli, by forming
surface active films able to reach and sustain very low surface tensions (< 2 mN m− 1) …

Surface chemistry of binary mixtures of phospholipids in monolayers. Infrared studies of surface composition at varying surface pressures in a pulmonary surfactant …

FR Rana, AJ Mautone, RA Dluhy - Biochemistry, 1993 - ACS Publications
Revised Manuscript Received January 11, 1993 abstract: Phospholipid monomolecular
films at the air/water interface were studied using Langmuir-Blodgett (LB) surface chemistry …

[HTML][HTML] A ToF-SIMS study of the lateral organization of lipids and proteins in pulmonary surfactant systems

E Keating, AJ Waring, FJ Walther, F Possmayer… - … et Biophysica Acta (BBA …, 2011 - Elsevier
Pulmonary surfactant is a complex lipid–protein mixture whose main function is to reduce
the surface tension at the air–liquid interface of alveoli to minimize the work of breathing …

[PDF][PDF] Rapid compression transforms interfacial monolayers of pulmonary surfactant

JM Crane, SB Hall - Biophysical journal, 2001 - cell.com
Films of pulmonary surfactant in the lung are metastable at surface pressures well above the
equilibrium spreading pressure of 45 mN/m but commonly collapse at that pressure when …

[PDF][PDF] Atomic force microscopy studies of functional and dysfunctional pulmonary surfactant films. I. Micro-and nanostructures of functional pulmonary surfactant films …

YY Zuo, E Keating, L Zhao, SM Tadayyon… - Biophysical journal, 2008 - cell.com
Monolayers of a functional pulmonary surfactant (PS) can reach very low surface tensions
well below their equilibrium value. The mechanism by which PS monolayers reach such low …