Background The transcription factor SOX11 plays an important role in embryonic
development of the central nervous system (CNS) and is expressed in the adult immature …

Sox2 regulates the self-renewal of multiple types of stem cells. Recent studies suggest it
also plays oncogenic roles in the formation of squamous carcinoma in several organs …

Previous studies have implicated cancer stem cells in tumor recurrence and revealed that
the stem cell gene SOX2 plays an important role in the tumor cell resistance to apoptosis …

Cancer stem cells (CSCs) have been reported in various cancers, including in skin
squamous-cell carcinoma (SCC),,,. The molecular mechanisms regulating tumour initiation …

SOX2 is a master pluripotency controller that was recently identified as a novel major
oncogene, recurrently amplified and activated in Squamous Cell Carcinoma (SCC). These …

Recent studies provide evidence that Sox4 is involved in regulating apoptosis as well as
tumorigenesis of various human cancers; however, its role in the apoptotic machinery is not …

Sox2 is known as the undifferentiated cell marker. Recent studies have shown that Sox2
may also be involved in the maintenance of cancer stem cells (CSCs) in skin and bladder …

To discover mechanisms that mediate plasticity in mammary cells, we characterized
signaling networks that are present in the mammary stem cells responsible for fetal and …

Objective The aim of the this study was to analyze the status of sex-determining region Y-
related high-mobility group box 4 (SOX4) expression in varied human cancers and its …

Sox2 expression marks gastric stem and progenitor cells, raising important questions
regarding the genes regulated by Sox2 and the role of Sox2 itself during stomach …