Latanoprost, a new ocular hypotensive prostaglandin F2α, analogue prodrug, was found to
induce increased pigmentation of monkey irides in chronic toxicity studies. This prompted us …

Latanoprost, a phenyl-substituted analogue of prostaglandin F2α administered as eye
drops, in-duces increased melanogenesis in the iridial melanocytes of monkeys. Similar …

The new glaucoma drugs latanoprost, isopropyl unoprostone, travoprost, and bimatoprost
cause increased pigmentation of the iris in some patients. The purpose of the present article …

Latanoprost, the active principle of XalatanR eye drops, is a prostaglandin F2α analogue in
widespread use for the treatment of glaucoma. During chronic treatment with the drug, an …

Several prostaglandin analogues used for glaucoma treatment cause increased
pigmentation of the iris. The purpose of the present study was investigate whether …

Low doses of naturally occurring prostaglandins reduce the intraocular pressure (IOP) in
many species. Species differences do occur both in terms of efficiency and mechanism of …

The melanocytes in the mammalian eye have been thought to produce melanin only during
fetal development and in the very young individual. The recent discovery that latanoprost, a …

Purpose: To present a case in which iris pigmentation developed after treatment with
isopropyl unoprostone, an analogue of a prostaglandin metabolite. Methods: Case report …

Purpose: To determine efficacy and safety of latanoprost, a prostaglandin analog for
glaucoma, during 1 year of treatment. Methods: After baseline measurements, 0.005 …

Latanoprost is a prostaglandin analogue with well-established efficacy in the treatment of
open-angle glaucoma and ocular hypertension. Once-daily administration of this drug for up …