Abstract Interferon regulatory factor 1 (IRF1) has been suggested to act as a tumor
suppressor in human cancers. However, the clinical significance and biological function of …

Abstract IFN regulatory factor (IRF)-1 and IRF-2 are generally regarded as a tumor
suppressor and an oncoprotein, respectively. However, little is known about their expression …

Abstract Interferon regulatory factor 2 (IRF-2) is known to play a pivotal role in the
development and progression of several malignancies. As a crucial member of interferon …

IRF1 is a transcription factor well known for its role in IFN signaling. Although IRF1 was
initially identified for its involvement in inflammatory processes, there is now evidence that it …

Objective Pancreatic cancer is one of the most malignant diseases worldwide. Interferon
regulatory factor (IRF) 1 and IRF2 function as a tumor suppressor and oncoprotein …

Pancreatic cancer is one of the most malignant diseases in the world. Interferon regulator
factor 2 (IRF-2), an interferon regulatory factor, has been known to act as an oncogene in …

Radiation is one of the main methods for the treatment of colorectal cancer (CRC) before or
after surgery. However, radiotherapy tolerance of patients with CRC is often a major …

Objectives The interferon regulatory factor (IRF) family of proteins are involved in tumor
progression. However, the role of IRF5 in tumorigenesis remains unknown. In this study we …

Background Interferon regulatory factor 1 (IRF-1) has been demonstrated to possess
antiproliferative and tumor suppressor functions, on the contrary, IRF-2 has been suggested …

Background Interferon regulatory factor (IRF)-1 and IRF-2 are transcriptional factors that
mediate interferons functions; the loss of IRF-1 expression and gain of IRF-2 expression …