Background Chronic intake of alcohol increases the risk of gastrointestinal and hepatic
carcinogenesis. The present study was focused to investigate the incidence and mechanism …

Background: Chronic ethanol consumption increases the risk of hepatic cirrhosis and
hepatocellular carcinoma (HCC). While sex differences exist in susceptibility to ethanol …

Background: Alcohol is a significant risk factor for the development of hepatocellular
carcinoma (HCC). To date, no rodent model has demonstrated the formation of hepatic …

Although primary hepatoma is not very frequent in alcoholics, the incidence of hepatoma in
cases of hepatitis B infection combined with heavy alcohol drinking is high. In the present …

Chronic and excessive alcohol consumption has been related to an increased risk of several
cancers, including that of the liver; however, studies in animal models have yet to …

An excessive alcohol intake may result in fatty liver, acute/chronic hepatitis, cirrhosis, and
lead to hepatocellular carcinoma (HCC). The aim of this review is to clarify the present …

AIM: To establish a mouse model of alcohol-driven hepatocellular carcinoma (HCC) that
develops in livers with alcoholic liver disease (ALD). METHODS: Adult C57BL/6 male mice …

The purpose of this report is to summarize the roles of alcohol and tobacco exposure in the
development of hepatocellular carcinoma (HCC). Chronic heavy alcohol exposure is a …

Hepatocellular carcinoma (HCC) is a significant cause of cancer-related morbidity and
mortality. Chronic, heavy ethanol consumption is a major risk for developing the worsening …

Although alcohol effects within the liver have been extensively studied, the complex
mechanisms by which alcohol causes liver cancer are not well understood. It has been …