Background p53, a commonly mutated gene in human cancers, participates in cell cycle
arrest, DNA repair and apoptosis. A small pharmacological compound, CP‐31398, was …

Mutations in the tumor suppressor p53 are detectable in over 50% of all human
malignancies. Mutant p53 protein is incapable of transactivating its downstream target …

Mutations in ras and p53 are the most prevalent mutations found in human nonmelanoma
skin cancers. Although some p53 mutations cause a loss of function, most result in …

Cutaneous malignant melanoma is a life-threatening cancer with poor prognosis due to a
high metastasis potential. The main obstacle in treatment of metastatic melanoma is the …

The p53 pathway is aberrant in most human tumours with over 50% expressing mutant p53
proteins. The pathway is critically controlled by protein degradation. Here, we discuss the …

The p53 protein plays a major role in the maintenance of genome stability in mammalian
cells. Mutations of p53 occur in over 50% of all cancers and are indicative of highly …

Around half of all human tumours carry mutant p53. This allows escape from p53-induced
cell cycle arrest and apoptosis. Many tumours express mutant p53 proteins at elevated …

Expression of the cellular p53 tumour‐suppressor protein was examined in 78 epidermal
tumours, including basal and squamous cell carcinomas, keratoacanthomas, solar …

Tumor suppressor p53 is a transcription factor that regulates a large number of genes and
guards against genomic instability. Under multiple cellular stress conditions, p53 functions to …

The p53 tumor suppressor pathway blocks tumor development by triggering apoptosis or
cellular senescence in response to oncogenic stress. A large fraction of human tumors carry …