Somatostatin receptors (SSTRs) are G‑protein‑coupled plasma membrane receptors that
have been determined to be expressed in normal and cancer tissues. Activation of SSTRs …

Somatostatin receptors (SSTRs) are inhibitory G-protein coupled receptors that are
ubiquitously expressed in normal and cancer cells. Somatostatins (SST) are the natural …

The somatostatin receptor subtype 2 (SSTR2) was detected in a wide range of human and
rat tumors using in vitro receptor binding ([125 I] MK-678), receptor gene expression …

Functional somatostatin receptors (SSTR) are lost in human pancreatic cancer. Transfection
of SSTR‐1 inhibited pancreatic cancer cell proliferation in vitro. We hypothesize that stable …

Aim: Somatostatin receptor subtype 2 (SSTR2) is the principal mediator of somatostatin's
(SST) antiproliferative effects on normal and cancer cells. Therefore, we investigated …

Somatostatin (SST) mediates cytostatic and pro-apoptotic effects through five somatostatin
receptors (SSTR1-5). The modest clinical benefits of SST analogs in cancers of different …

Somatostatin (SST) via five Gi coupled receptors namely SSTR1-5 is known to inhibit cell
proliferation by cytostatic and cytotoxic mechanisms. Heterodimerization plays a crucial role …

Background. Somatostatin receptors (SSTR1-5) are inhibitory G-protein coupled receptors
that are ubiquitously expressed in both normal and cancer cells. Activation of SSTRs results …

Genes for five somatostatin receptor subtypes, designated sst1–5, have been cloned and
shown to belong to the seven transmembrane domain receptor family. The sst2 mRNA …

Although in situ hybridization has been used to examine the distribution of messenger RNA
for somatostatin receptor subtypes (sst) in human tumors, the cellular localization of sst1 and …