Genome-wide association studies on endometriosis and endometriosis-related infertility
G Galarneau, P Fontanillas, Celmatix Research Team… - BioRxiv, 2018 - biorxiv.org
Endometriosis affects∼ 10% of women of reproductive age. It is characterized by the growth
of endometrial-like tissue outside the uterus and is frequently associated with severe pain …
of endometrial-like tissue outside the uterus and is frequently associated with severe pain …
Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets
BACKGROUND Endometriosis is a heritable common gynaecological condition influenced
by multiple genetic and environmental factors. Genome-wide association studies (GWASs) …
by multiple genetic and environmental factors. Genome-wide association studies (GWASs) …
Independent replication and meta-analysis for endometriosis risk loci
Y Sapkota, A Fassbender, L Bowdler… - Twin Research and …, 2015 - cambridge.org
Endometriosis is a complex disease that affects 6–10% of women in their reproductive years
and 20–50% of women with infertility. Genome-wide and candidate-gene association …
and 20–50% of women with infertility. Genome-wide and candidate-gene association …
Large-scale genome-wide association meta-analysis of endometriosis reveals 13 novel loci and genetically-associated comorbidity with other pain conditions
Endometriosis is a common complex inflammatory condition characterised by the presence
of endometrium-like tissue outside the uterus, mainly in the pelvic area. It is associated with …
of endometrium-like tissue outside the uterus, mainly in the pelvic area. It is associated with …
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism
Endometriosis is a heritable hormone-dependent gynecological disorder, associated with
severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely …
severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely …
Therapeutic targets for endometriosis: Genome-wide Mendelian randomization and colocalization analyses
P Zeng, L Lu, H Zhang, Y Li, S Tan, T Yu, H Zhou - Gene, 2024 - Elsevier
Background Endometriosis (EM) greatly affects women's reproductive health, identifying
new drug targets for EM is urgently needed. This study utilizes comprehensive genome-wide …
new drug targets for EM is urgently needed. This study utilizes comprehensive genome-wide …
Enhancing Genetic Association Power in Endometriosis through Unsupervised Clustering of Clinical Subtypes Identified from Electronic Health Records
Background: Endometriosis affects 10% of reproductive-age women, and yet, it goes
undiagnosed for 3.6 years on average after symptoms onset. Despite large GWAS meta …
undiagnosed for 3.6 years on average after symptoms onset. Despite large GWAS meta …
Identifying the biological basis of GWAS hits for endometriosis
JN Fung, PAW Rogers… - Biology of …, 2015 - academic.oup.com
Endometriosis is a common estrogen-dependent gynecological disease influenced by
multiple genetic and environmental factors. Genome-wide association studies (GWAS) have …
multiple genetic and environmental factors. Genome-wide association studies (GWAS) have …
Genome-wide association study link novel loci to endometriosis
HM Albertsen, R Chettier, P Farrington, K Ward - PloS one, 2013 - journals.plos.org
Endometriosis is a common gynecological condition with complex etiology defined by the
presence of endometrial glands and stroma outside the womb. Endometriosis is a common …
presence of endometrial glands and stroma outside the womb. Endometriosis is a common …
Beyond endometriosis genome-wide association study: from genomics to phenomics to the patient
Endometriosis is a heritable, complex chronic inflammatory disease, for which much of the
causal pathogenic mechanism remains unknown. Genome-wide association studies …
causal pathogenic mechanism remains unknown. Genome-wide association studies …