The Gene-Environment Nexus: A Holistic Approach to Neurodegenerative Diseases

H Abdelzaher - Nutrigenomics and the Brain, 2022 - Springer
Neurodegenerative diseases affect millions of people globally and are characterized by their
poor prognosis and decreased quality of life. In the quest to shed light on the development …

Environmental Effect on Neuroinflammation and Neurodegeneration

MR Langley, S Rangaraju, A Dey… - Frontiers in Cellular …, 2022 - frontiersin.org
Neurodegenerative disorders like Parkinson's disease and Alzheimer's disease, among
others, are characterized by the loss of a specific subset of neurons and glial activation …

Environmental clues to brain disease

P Giannoni, F Bertaso, G Provensi - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
Brain disease represents one of the major social and economic burden worldwide.
Identifying the factors impacting brain homeostasis, as well as the mechanisms involved in …

[HTML][HTML] Gene-by-environment interactions in Alzheimer's disease and Parkinson's disease

AR Dunn, KMS O'Connell, CC Kaczorowski - … & Biobehavioral Reviews, 2019 - Elsevier
Diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) arise from
complex interactions of genetic and environmental factors, with genetic variants regulating …

Advances in understanding the pathogenetic mechanisms of neurodevelopmental disorders and neurodegenerative disease—The environment as a putative risk …

AM Lavezzi, M Colizzi, PJ Lein - Frontiers in Neurology, 2023 - frontiersin.org
Neurodevelopmental disorders are generally influenced by not only genetic, but also
intrauterine and extrauterine factors that affect the fetal-maternal environment and/or brain …

Genes and the environment in neurodegeneration

F Coppede, M Mancuso, G Siciliano… - Bioscience …, 2006 - portlandpress.com
Neurodegenerative diseases are a heterogeneous group of pathologies which includes
complex multifactorial diseases, monogenic disorders and disorders for which inherited …

Neuroinflammation represents a common theme amongst genetic and environmental risk factors for Alzheimer and Parkinson diseases

RJ Boyd, D Avramopoulos, LL Jantzie… - Journal of …, 2022 - Springer
Multifactorial diseases are characterized by inter-individual variation in etiology, age of
onset, and penetrance. These diseases tend to be relatively common and arise from the …

Genetics meets environment: evaluating gene–environment interactions in neurologic diseases

C Marras, SM Goldman - Seminars in neurology, 2011 - thieme-connect.com
The vast majority of disease is due to complex relationships between genetic and
environmental factors. Single genetic or environmental causes are rare. Unfortunately, this …

Nature versus nurture: death of a dogma, and the road ahead

BJ Traynor, AB Singleton - Neuron, 2010 - cell.com
Interaction between the genome and the environment has been widely discussed in the
literature, but has the importance ascribed to understanding these interactions been …

Role of early life exposure and environment on neurodegeneration: implications on brain disorders

S Modgil, DK Lahiri, VL Sharma, A Anand - Translational …, 2014 - Springer
Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD),
Amyotrophic lateral sclerosis (ALS) and retinal degeneration have been studied extensively …