In the face of the current obesity epidemic, the nature of the relationship between
overnutrition and type 2 diabetes is of great importance. Obesity can be considered a state …

Obesity-associated insulin resistance is a major risk factor for type 2 diabetes and
cardiovascular disease. In the past decade, a large number of endocrine, inflammatory …

Obesity represents a major risk factor for the development of insulin and leptin resistance,
ultimately leading to a pleiotropic spectrum of metabolic alterations. However, resistance to …

The past decade or so has seen the adipocyte catapulted from a position of relative
obscurity onto the centre stage of biomedical science. Having long been viewed largely as a …

Obesity genes and insulin resistance : Current Opinion in Endocrinology, Diabetes and
Obesity Obesity genes and insulin resistance : Current Opinion in Endocrinology, Diabetes …

Nutritional excess is a major forerunner of type 2 diabetes. It enhances the secretion of
insulin, but attenuates insulin's metabolic actions in the liver, skeletal muscle and adipose …

Insulin resistance is an important contributor to the pathogenesis of T2D and obesity is a risk
factor for its development. It has been demonstrated that these obesity-related metabolic …

Obesity is a triggering factor for diabetes associated with insulin resistance. In individuals
who are obese, higher amounts of non-esterified fatty acids, glycerol, hormones, and pro …

The consumption of W estern diets, high in sugar and saturated fat, is a crucial contributor to
the alarming incidence of obesity and its associated morbidities. These diets have been …

Insulin and leptin play complementary roles in regulating the consumption, uptake, oxidation
and storage of nutrients. Chronic consumption of diets that contain a high proportion of …