The blood–brain barrier (BBB) is composed of a network of tight junctions (TJ) which
interconnect cerebral endothelial cells (EC). Alterations in the TJ proteins are common in …

Objective: Dimethyl fumarate (DMF) is prescribed against relapsing-remitting multiple
sclerosis (MS). Here, we investigated the effects of DMF and monomethyl fumarate (MMF) …

Dimethyl fumarate (DMF) is approved for disease-modifying treatment of patients with
relapsing-remitting multiple sclerosis. Animal experiments suggested that part of its …

Background Reactive oxygen species play a key role in the pathogenesis of multiple
sclerosis as they induce blood–brain barrier disruption and enhance transendothelial …

Brain edema is a hallmark of various neuropathologies, but the underlying mechanisms are
poorly understood. We aim to characterize how tissue hypoxia, together with oxidative stress …

Inflammation and oxidative stress are thought to promote tissue damage in multiple
sclerosis. Thus, novel therapeutics enhancing cellular resistance to free radicals could prove …

Oxidative stress plays a crucial role in many neurodegenerative conditions such as
Alzheimer's disease, amyotrophic lateral sclerosis and Parkinson's as well as Huntington's …

Oxidative stress is a hallmark of ischemic stroke pathogenesis causing neuronal malfunction
and cell death. Up-regulation of anti-oxidative genes through activation of the NF-E2-related …

Homeostasis within the central nervous system (CNS) is a prerequisite to elicit proper
neuronal function. The CNS is tightly sealed from the changeable milieu of the blood stream …

Background Brain inflammation plays a central role in multiple sclerosis (MS).
Dimethylfumarate (DMF), the main ingredient of an oral formulation of fumaric acid esters …