Inhibition of apolipoprotein B and triglyceride secretion in human hepatoma cells (HepG2).

M Haghpassand, D Wilder, JB Moberly - Journal of lipid research, 1996 - ASBMB
Apolipoprotein B (apoB), the major protein component of triglyceride-rich lipoproteins, is
assembled into a lipoprotein particle via a complex, multistep process. Recent studies …

Suppression of cytosolic triacylglycerol recruitment for very low density lipoprotein assembly by inactivation of microsomal triglyceride transfer protein results in a …

AM Hebbachi, AM Brown, GF Gibbons - Journal of lipid research, 1999 - ASBMB
Cellular apoB in primary rat hepatocyte cultures was pulse-labeled with [35 S] methionine
for 1 h. Cells were then chased with excess unlabeled methionine for periods of up to 16 h in …

Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by …

DA Gordon, H Jamil, D Sharp… - Proceedings of the …, 1994 - National Acad Sciences
To elucidate the role of the microsomal triglyceride transfer protein (MTP) in lipoprotein
assembly, MTP and apolipoprotein B-53 (apoB 53; the N-terminal 53% of apoB) were …

Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the …

DA Gordon, H Jamil, RE Gregg, SO Olofsson… - Journal of Biological …, 1996 - ASBMB
The microsomal triglyceride transfer protein (MTP) is required for assembly and secretion of
the lipoproteins containing apolipoprotein B (apoB): very low density lipoproteins and …

Identification of domains in apolipoprotein B100 that confer a high requirement for the microsomal triglyceride transfer protein

E Nicodeme, F Benoist, R McLeod, Z Yao… - Journal of Biological …, 1999 - ASBMB
The microsomal triglyceride transfer protein (MTP) is required for the assembly and
secretion of apoB-containing lipoproteins. To investigate the role of MTP in lipoprotein …

Decreased Secretion of ApoB Follows Inhibition of ApoB− MTP Binding by a Novel Antagonist

A Bakillah, N Nayak, U Saxena, RM Medford… - Biochemistry, 2000 - ACS Publications
Apolipoprotein B (apoB) and microsomal triglyceride transfer protein (MTP) are essential for
the efficient assembly of triglyceride-rich lipoproteins. Evidence has been presented for …

Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly

MM Hussain, J Shi, P Dreizen - Journal of lipid research, 2003 - ASBMB
Apolipoprotein B (ap1111190) and microsomal triglyceride transfer protein (MTP) are
necessary for lipoprotein assembly. ApoB consists of five structural domains, βα 1-β 1-α 2-β …

Microsomal triglyceride transfer protein activity is not required for the initiation of apolipoprotein B-containing lipoprotein assembly in McA-RH7777 cells

N Dashti, M Manchekar, Y Liu, Z Sun… - Journal of Biological …, 2007 - ASBMB
We previously demonstrated that the N-terminal 1000 amino acid residues of human
apolipoprotein (apo) B (designated apoB: 1000) are competent to fold into a three-sided …

An inhibitor of the microsomal triglyceride transfer protein inhibits apoB secretion from HepG2 cells.

H Jamil, DA Gordon, DC Eustice… - Proceedings of the …, 1996 - National Acad Sciences
The microsomal triglyceride (TG) transfer protein (MTP) is a heterodimeric lipid transfer
protein that catalyzes the transport of triglyceride, cholesteryl ester, and phosphatidylcholine …

Microsomal triglyceride transfer protein is essential for hepatic secretion of apoB-100 and apoB-48 but not triglyceride

TY Hui, LM Olivier, S Kang, RA Davis - Journal of lipid research, 2002 - ASBMB
Despite a complete lack of microsomal triglyceride transfer protein (MTP), L35 rat hepatoma
cells secrete triglyceride-containing lipoproteins, albeit at a rate 25% of that of parental FAO …