Hydrosalpinx induction in mice by Chlamydia muridarum infection, a model that has been
used to study C. trachomatis pathogenesis in women, is known to depend on the cryptic …

We have previously shown that the plasmid-encoded Pgp3 is a major virulence factor for C.
muridarum induction of hydrosalpinx. We now report that Pgp5 also plays a significant role …

Transformation of Chlamydia trachomatis should greatly advance the chlamydial research.
However, significant progress has been hindered by the failure of C. trachomatis to induce …

The cryptic plasmid is essential for Chlamydia muridarum dissemination from the genital
tract to the gastrointestinal (GI) tract. Following intravaginal inoculation, a C. muridarum …

Most Chlamydia species carry a 7.5 kb plasmid encoding eight open reading frames
conventionally called plasmid glycoproteins 1–8 or pGP1–8. Although the plasmid is not …

Plasmid-free Chlamydia trachomatis and Chlamydia muridarum fail to induce severe
pathology. To evaluate whether the attenuated pathogenicity is due to insufficient infection …

Although Chlamydia trachomatis is a human genital tract pathogen, chlamydial organisms
have frequently been detected in both vaginal and rectal swab samples of animals and …

Chlamydia trachomatis and C. muridarum are human and mouse pathogens, respectively,
which show high conservation of gene order and content. Both species contain a common …

Chlamydia trachomatis causes chronic inflammatory diseases of the eye and genital tract
and has global medical importance. The chlamydial plasmid plays an important role in the …

Hydrosalpinx is a pathological hallmark of tubal infertility associated with chlamydial
infection. However, the mechanisms of hydrosalpinx remain unknown. Here, we report that …