Macrophages are highly plastic cells critical for the development of rheumatoid arthritis (RA).
Macrophages exhibit a high degree of pro-inflammatory plasticity in RA, accompanied by a …

O-GlcNAcylation is a reversible post-translational modification that regulates numerous
cellular processes, including embryonic development as well as immune responses …

Objective This study aimed to evaluate glycolysis inhibitor which can effectively ameliorate
arthritis by inhibiting synoviocyte activation through AMPK/NF-кB pathway in AA rats …

Objective: Glucosamine sulfate (GS) is a commonly used drug for the treatment of
osteoarthritis. The mechanism of the action of this drug does, however, remain to be …

Dysfunction of macrophage polarization majorly contributes to the progression of
rheumatoid arthritis (RA). Polarization and functions of activated macrophages are closely …

We recently reported that glucosamine reversed the decrease in proteoglycan synthesis and
in UDP‐glucuronosyltransferase I mRNA expression induced by interleukin‐1β (IL …

The aim of this study was to determine the effects of glucosamine on matrix metalloprotease
(MMP) production, on mitogen-activated protein kinase (MAPK) phosphorylation, and on …

Objective To investigate the role of glycogen metabolism in regulating rheumatoid fibroblast-
like synoviocyte (FLS)-mediated synovial inflammation and its underlying mechanism …

The K/BxN mouse is a spontaneous model of arthritis driven by T cell receptor transgenic
CD4+ T cells from the KRN strain that are activated by glucose-6-phosphate isomerase …

Glutamine metabolism and the mechanistic target of rapamycin (mTOR) pathway are
activated cooperatively in the differentiation and activation of inflammatory immune cells. But …