Recent studies indicate that glucose metabolism is altered in rheumatoid arthritis. We
hypothesize that Pkm2, as a key regulatory enzyme of glycolysis pathway, triggers the …

Rheumatoid arthritis (RA) is significantly associated with glycolysis. This study used 2-deoxy-
D-glucose (2-DG), an inhibitor of glycolysis, to treat rats with collagen-induced arthritis (CIA) …

Objective Human adult articular cartilage (AC) has little capacity for repair, and joint surface
injuries often result in osteoarthritis (OA), characterised by loss of matrix, hypertrophy and …

Objective Glucosamine is a naturally occurring amino monosaccharide that maintains the
elasticity and strength of the cartilage tissues. It has been used to treat osteoarthritis in …

The purpose of this study was to investigate the possible involvement of synovium in
cartilage destruction in osteoarthritis (OA) patients. Using human primary synovial fibroblasts …

Introduction The mono-and digalactosyldiacylglycerol (MGDG and DGDG) galactolipids
have been purified from the thermophilic blue-green alga Phormidium sp. ETS-05 that …

Objective: Recently, we found that administration of glucosamine to adjuvant arthritis, a
model for rheumatoid arthritis, suppressed the progression of arthritis in rats. To clarify its …

Osteoarthritis (OA) is an entire joint disease with pathological alteration in both articular
cartilage and subchondral bone. It has been recognized recently the association between …

Glucosamine, an amino monosaccharide naturally occurring in the connective and cartilage
tissues, contributes to maintaining the strength, flexibility, and elasticity of these tissues. In …

Osteoarthritis (OA) commonly affects the synovial joint and is characterized by degradation
of articular cartilage. Increased matrix metalloproteinase (MMP) activity plays a major role in …