Osteoarthritis (OA) is a common chronic inflammatory disease, characterized by cartilage
degradation. The aberrant expression of matrix metalloproteinase-13 (MMP-13) plays a vital …

Background Changes of serum concentrations of glycated, oxidized, and nitrated amino
acids and hydroxyproline and anticyclic citrullinated peptide antibody status combined by …

Introduction Peroxisome proliferator-activated receptor (PPAR) agonists are widely used
drugs in the treatment of diabetes and dyslipidemia. In addition to their metabolic effects …

Inflammation is an energy-intensive process, and caloric restriction (CR) could provide anti-
inflammatory benefits. CR mimetics (CRM), such as the glycolytic inhibitor 2-deoxyglucose …

G protein-coupled receptors (GPCR) play a crucial role in the regulation of the immune
response by, eg, chemokines, PGs, and β 2-adrenergic agonists. The responsiveness of …

Introduction Fibroblast-like synoviocytes (FLS) play an important role in the pathogenesis of
rheumatoid arthritis (RA). This study aimed to investigate the role of glucose 6-phosphate …

Introduction Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of the
joints and bones. Omega-3 (ω3) fatty acid supplementation has been associated with a …

OA is now well accepted as a low-grade inflammatory disease affecting the whole joint. In
addition to mechanical loading, inflammation (particularly synovitis), contributes significantly …

OBJECTIVE: To study the effects of oral glucosamine sulfate on the development of
osteoarthritis (OA) and to examine concomitant changes in the nociceptive behavior of rats …

Osteoarthritis (OA) is a serious and frequently occurring disease in the elderly, characterized
by cartilage degeneration and proliferation of bone structure. Glycyrrhizin, a compound …