Abstract Background and Aim Mitochondrial dysfunction contributes to the pathophysiology
of diabetic cardiomyopathy. The aim of this study was to investigate the acute changes in the …

Diabetic cardiomyopathy is a common complication leading to heightened risk of heart
failure and death. In the present report, we performed proteomic analysis on total cardiac …

Cardiac complications and heart failure are the leading cause of death in type 2 diabetic
patients. Mitochondrial dysfunction is central in the pathogenesis of the type 2 diabetic heart …

Reactive oxygen species resulting from diabetes mellitus contribute to damage and loss of
mitochondrial proteins. Two spatially distinct mitochondria populations exist in the cardiac …

Diabetic cardiomyopathy (DCM) occurs independently of coronary artery disease or
hypertension, often leading to heart failure and death. Although remarkable progress has …

OBJECTIVE To elucidate the molecular basis for mitochondrial dysfunction, which has been
implicated in the pathogenesis of diabetes complications. RESEARCH DESIGN AND …

Objective: Impaired mitochondrial function may contribute to the onset of contractile
dysfunction with insulin resistance/type 2 diabetes. Our aim was therefore to determine …

Aims Mitochondrial dysfunction is an important part of the decline in cardiac function in heart
failure. We hypothesized for hypothesized that there would be specific abnormalities in …

Abstract Funding Acknowledgements Type of funding sources: Public grant (s)–National
budget only. Main funding source (s): INSERM U1060 Introduction The prevalence of type 2 …

Diabetes mellitus is a complex metabolic disorder characterized by chronic hyperglycemia
due to absolute or relative lack of insulin. Though great efforts have been made to …