Abstract Persistent, Bioaccumulative and Toxic (PBT) and very Persistent and very
Bioaccumulative (vPvB) are regulatory hazard categories that have been set to manage the …

There is currently limited guidance available for regulators and risk assessors on how to use
data from non-guideline methods when assessing the bioaccumulation potential of a …

Abstract In the European Medicines Agency (EMA)“Guideline for Environmental Risk
Assessment of Medicinal Products for Human Use,” a fish bioconcentration factor (BCF) …

The bioaccumulation potential is an important criterion in risk assessment of chemicals.
Several regressions between bioconcentration factor (BCF) in fish and octanol–water …

Bioaccumulation is one of the three criteria for the PBT assessment of chemicals, where P
stands for persistence, B for bioaccumulation, and T for toxicity, which is a cornerstone for …

Worldwide, regulations of chemicals require short-term toxicity data for evaluating hazards
and risks of the chemicals. Current data requirements on the registration of chemicals are …

Bioaccumulation plays a vital role in understanding the fate of a substance in the
environment and is key to the regulation of chemicals in several jurisdictions. The current …

A compound's bioconcentration factor (BCF) is the most commonly used indicator of its
tendency to accumulate in aquatic organisms from the surrounding medium. Because it is …

A new methodology to evaluate the overall environmental hazard of unknown mixtures,
based on bioconcentration potential and toxicity, was developed using a combination of two …

Currently, the laboratory‐derived fish bioconcentration factor (BCF) serves as one of the
primary data sources used to assess the potential for a chemical to bioaccumulate …