Growth inhibitory effect of celecoxib and rofecoxib on human colorectal carcinoma cell lines
B Buecher, D Bouancheau, A Broquet… - Anticancer …, 2005 - ar.iiarjournals.org
Background: Epidemiological studies have revealed a protective effect of NSAIDs, which
principally target cyclooxygenase (COX)-1 and COX-2, on the development of colorectal …
principally target cyclooxygenase (COX)-1 and COX-2, on the development of colorectal …
Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis
BS Reddy, Y Hirose, R Lubet, V Steele, G Kelloff… - Cancer research, 2000 - AACR
Epidemiological observations and laboratory research have suggested that nonsteroidal
anti-inflammatory drugs (NSAIDs) reduce the risk of colon cancer and that the inhibition of …
anti-inflammatory drugs (NSAIDs) reduce the risk of colon cancer and that the inhibition of …
COX‐2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX‐2 inhibitor celecoxib
S Grösch, I Tegeder, E Niederberger… - The FASEB …, 2001 - Wiley Online Library
The regular use of various nonsteroidal anti‐inflammatory drugs (NSAIDs) was shown to
decrease the incidence of colorectal cancer. This effect is thought to be caused …
decrease the incidence of colorectal cancer. This effect is thought to be caused …
COX-2 inhibition as a tool to treat and prevent colorectal cancer
JB Tuynman, MP Peppelenbosch, DJ Richel - Critical reviews in oncology …, 2004 - Elsevier
The cyclooxygenase-2 (COX-2) enzyme has a fundamental role in the carcinogenesis of
colorectal cancer. The anticarcinogenic mechanisms of NSAIDs are not completely …
colorectal cancer. The anticarcinogenic mechanisms of NSAIDs are not completely …
Cyclooxygenase-2 (COX-2) in carcinogenesis and selective COX-2 inhibitors for chemoprevention in gastrointestinal cancers
T Fujimura, T Ohta, K Oyama, T Miyashita… - Journal of gastrointestinal …, 2007 - Springer
Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to have a
property to inhibit tumor development in some cancers while it shows various side effects …
property to inhibit tumor development in some cancers while it shows various side effects …
Celecoxib But Not Rofecoxib Inhibits the Growth of Transformed Cells in Vitro
D Kazanov, H Dvory-Sobol, M Pick, E Liberman… - Clinical cancer …, 2004 - AACR
Purpose: Nonsteroidal anti-inflammatory drugs reduce the risk of colorectal cancer. The
cyclooxygenase (COX) pathway of arachidonic acid metabolism is an important target for …
cyclooxygenase (COX) pathway of arachidonic acid metabolism is an important target for …
COX-2 inhibitor and colon cancer
M Tsujii - Gan to Kagaku ryoho. Cancer & Chemotherapy, 2001 - europepmc.org
It is suggested that nonsteroidal antiinflammatory inhibitors alter the biology of colorectal
carcinogenesis. Cyclooxygenase-2, one of target molecules of these drugs, is reported to be …
carcinogenesis. Cyclooxygenase-2, one of target molecules of these drugs, is reported to be …
COX-2 as a molecular target of colon cancer chemoprevention: Promise and reality
The decisive epidemiological observation that non-steroidal anti-inflammatory drugs
(NSAIDs) prevent colon and possibly other cancers as well has spurred novel approaches to …
(NSAIDs) prevent colon and possibly other cancers as well has spurred novel approaches to …
Inhibition of cyclooxygenase-2 by rofecoxib attenuates the growth and metastatic potential of colorectal carcinoma in mice
M Yao, S Kargman, EC Lam, CR Kelly, Y Zheng, P Luk… - Cancer research, 2003 - AACR
A large number of epidemiological studies have shown that regular use of aspirinor other
nonsteroidal anti-inflammatory drugs (NSAIDs) results in a 40–50% reduced risk of …
nonsteroidal anti-inflammatory drugs (NSAIDs) results in a 40–50% reduced risk of …
Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis
T Kawamori, CV Rao, K Seibert, BS Reddy - Cancer research, 1998 - AACR
Epidemiological and laboratory studies suggest that nonsteroidal anti-inflammatory drugs
reduce the risk of colon cancer and that the inhibition of colon carcinogenesis is mediated …
reduce the risk of colon cancer and that the inhibition of colon carcinogenesis is mediated …