Hypoxia-ischemia (HI) is a leading cause of white matter damage, a major contributor to
cerebral palsy in premature infants. Preferential white matter damage is believed to result …

In the premature infant, hypoxic-ischemic damage to the cerebral white matter
[periventricular leukomalacia (PVL)] is a common and leading cause of brain injury that often …

Periventricular leukomalacia is the predominant injury in the preterm infant leading to
cerebral palsy. Oxygen exposure may be an additional cause of brain injury in these infants …

In the immature human brain, periventricular leukomalacia (PVL) is the predominant white
matter injury underlying the development of cerebral palsy. PVL has its peak incidence …

With significant improvements in neonatal care, fewer infants sustain severe injury as a
consequence of hypoxia/ischemia (H/I). However, the majority of experimental studies have …

Emerging evidence supports that premature infants are susceptible to both cerebral white
and gray matter injury. In a fetal rabbit model of placental insufficiency, preterm rabbits at …

Objective Abnormal myelination is a major pathological sequela of chronic periventricular
white matter injury in survivors of premature birth. We tested the hypothesis that myelination …

Studies of ischemic brain injury in neonatal rodents have focused upon the pathophysiology
of neuronal damage. Much less consideration has been given to white matter injury, even …

Cerebral hypoxia/ischemia of the newborn has a frequency of 4/1,000 births and remains a
major cause of cerebral palsy, epilepsy, and mental retardation. Despite progress in …

Neonatal hypoxia-ischemia in the preterm human leads to selective injury to the subcortical
developing white matter, which results in periventricular leukomalacia (PVL), a condition …