Regulation of p53, nuclear factor κB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin
N Kalra, K Bhui, P Roy, S Srivastava, J George… - Toxicology and applied …, 2008 - Elsevier
Bromelain is a pharmacologically active compound, present in stems and immature fruits of
pineapples (Ananas cosmosus), which has been shown to have anti-edematous, anti …
pineapples (Ananas cosmosus), which has been shown to have anti-edematous, anti …
Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway
Chemoprevention impels the pursuit for either single targeted or cocktail of multi-targeted
agents. Bromelain, potential agent in this regard, is a pharmacologically active compound …
agents. Bromelain, potential agent in this regard, is a pharmacologically active compound …
Bromelain-induced apoptosis in GI-101A breast cancer cells
S Dhandayuthapani, HD Perez, A Paroulek… - Journal of medicinal …, 2012 - liebertpub.com
Bromelain is a proteolytic enzyme extracted from the stems and the immature fruits of
pineapple that was found to be antitumorigenic in different in vitro models. Bromelain has …
pineapple that was found to be antitumorigenic in different in vitro models. Bromelain has …
Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-κB and AP-1: IκB kinase and c-Jun-N-terminal kinase as …
JC Lee, JK Kundu, DM Hwang, HK Na… - …, 2007 - academic.oup.com
Humulone, a bitter acid derived from hop (Humulus lupulus L.), possesses antioxidative, anti-
inflammatory and other biologically active activities. Although humulone has been reported …
inflammatory and other biologically active activities. Although humulone has been reported …
Bromelain's activity and potential as an anti-cancer agent: current evidence and perspectives
K Chobotova, AB Vernallis, FAA Majid - Cancer letters, 2010 - Elsevier
The medicinal qualities of pineapple are recognized in many traditions in South America,
China and Southeast Asia. These qualities are attributed to bromelain, a 95%-mixture of …
China and Southeast Asia. These qualities are attributed to bromelain, a 95%-mixture of …
Bromelain inhibits nuclear factor kappa‐B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G2/M arrest to apoptosis
K Bhui, S Tyagi, AK Srivastava, M Singh… - Molecular …, 2012 - Wiley Online Library
Bromelain, obtained from pineapple, is already in use clinically as adjunct in chemotherapy.
Our objective was to test its ability to act as a sole anti‐cancer agent. Therefore, we describe …
Our objective was to test its ability to act as a sole anti‐cancer agent. Therefore, we describe …
Xanthorrhizol inhibits 12- O -tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the …
WY Chung, JH Park, MJ Kim, HO Kim… - …, 2007 - academic.oup.com
Xanthorrhizol is an active component isolated from Curcuma xanthorrhiza
Roxb.(Zingiberaceae) that is traditionally used in Indonesia for medicinal purposes. In the …
Roxb.(Zingiberaceae) that is traditionally used in Indonesia for medicinal purposes. In the …
Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21)
A Amini, A Ehteda, S Masoumi Moghaddam… - OncoTargets and …, 2013 - Taylor & Francis
Background Bromelain is a pineapple stem extract with a variety of therapeutic benefits
arising from interaction with a number of different biological processes. Several preclinical …
arising from interaction with a number of different biological processes. Several preclinical …
Inhibitory effect of magnolol on TPA-induced skin inflammation and tumor promotion in mice
DH Kuo, YS Lai, CY Lo, AC Cheng, H Wu… - Journal of Agricultural …, 2010 - ACS Publications
Magnolol has been reported to have an anti-inflammatory and antitumor effect in vitro and in
vivo. Herein, we report the investigation of the inhibitory effects of magnolol on 12-O …
vivo. Herein, we report the investigation of the inhibitory effects of magnolol on 12-O …
Inhibitory effects of oligonol on phorbol ester-induced tumor promotion and COX-2 expression in mouse skin: NF-κB and C/EBP as potential targets
Plant polyphenols possess anti-oxidant and anti-inflammatory activities and are hence
potential candidates for preventing cancer. The present study was aimed at evaluating the …
potential candidates for preventing cancer. The present study was aimed at evaluating the …
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- cyclooxygenase 2 mouse skin
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