The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival
MJ Wheater, PWM Johnson… - Cancer biology & therapy, 2010 - Taylor & Francis
eIF4E is over-expressed in many tumours, including a high proportion of breast cancers.
eIF4E is an oncogene, and signalling pathways which promote eIF4E activity represent …
eIF4E is an oncogene, and signalling pathways which promote eIF4E activity represent …
Mnks, eIF4E phosphorylation and cancer
CG Proud - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2015 - Elsevier
The MAP kinase signal-integrating kinases or MAP kinase-interacting protein kinases
(Mnks) are activated by signaling through the oncogenic MAP kinase (ERK) pathway. The …
(Mnks) are activated by signaling through the oncogenic MAP kinase (ERK) pathway. The …
Mnk earmarks eIF4E for cancer therapy
N Hay - Proceedings of the National Academy of Sciences, 2010 - National Acad Sciences
The PI3K/Akt/mTORC1 axis is perhaps the most frequently activated pathway in human
cancers. Therefore, concerted efforts are being made to inhibit this pathway …
cancers. Therefore, concerted efforts are being made to inhibit this pathway …
[HTML][HTML] Targeting Mnks for cancer therapy
Deregulation of protein synthesis is a common event in human cancer and a key player in
translational control is eIF4E. Elevated expression levels of eIF4E promote cancer …
translational control is eIF4E. Elevated expression levels of eIF4E promote cancer …
Phosphorylation of the mRNA cap-binding protein eIF4E and cancer
X Yang, W Zhong, R Cao - Cellular signalling, 2020 - Elsevier
Dysregulated protein synthesis is frequently involved in oncogenesis and cancer
progression. Translation initiation is thought to be the rate-limiting step in protein synthesis …
progression. Translation initiation is thought to be the rate-limiting step in protein synthesis …
Progress in developing MNK inhibitors
The MNKs (mitogen-activated protein kinase-interacting protein kinases) phosphorylate
eIF4E (eukaryotic initiation factor 4 E) at serine 209; eIF4E plays an important role in the …
eIF4E (eukaryotic initiation factor 4 E) at serine 209; eIF4E plays an important role in the …
Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung …
BW Konicek, JR Stephens, AM McNulty, N Robichaud… - Cancer research, 2011 - AACR
Activation of the translation initiation factor 4E (eIF4E) promotes malignant transformation
and metastasis. Signaling through the AKT-mTOR pathway activates eIF4E by …
and metastasis. Signaling through the AKT-mTOR pathway activates eIF4E by …
Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissues
S Fan, SS Ramalingam, J Kauh, Z Xu… - Cancer biology & …, 2009 - Taylor & Francis
Eukaryotic translation initiation factor 4E (eIF4E) is a rate-limiting factor for cap-dependent
protein synthesis and is regulated by PI3 kinase/mTOR and mitogen-activated protein …
protein synthesis and is regulated by PI3 kinase/mTOR and mitogen-activated protein …
Phosphorylation of mammalian eIF4E by Mnk1 and Mnk2: tantalizing prospects for a role in translation
M Mahalingam, JA Cooper - Signaling Pathways for Translation: Stress …, 2001 - Springer
One of the first translation initiation factors shown to be phosphorylated in mitogen-
stimulated mammalian cells was eukaryotic translation initiation factor 4E (eIF4E), the mRNA …
stimulated mammalian cells was eukaryotic translation initiation factor 4E (eIF4E), the mRNA …
The MAP kinase-interacting kinases (MNKs) as targets in oncology
Introduction: The mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs) are
switched on by the oncogenic MAPK (ERK) signalling pathway. They phosphorylate …
switched on by the oncogenic MAPK (ERK) signalling pathway. They phosphorylate …