Metastatic disease is the leading cause of death in cancer patients. Metastasis formation
involves a cascade of events for which the underlying mechanisms are still poorly …

Metastatic disease is the leading cause of death among cancer patients and involves a
complex and inefficient process. Every step of the metastatic process can be rate limiting …

Metastasis, which occurs when cancer cells disseminate from the primary tumor site to other
parts of the body, is the primary cause of mortality in patients, and the recurrence of multiple …

Metastatic disease is responsible for approximately 90% of cancer deaths. For successful
dissemination and metastasis, cancer cells must evade detection and destruction by the …

Simple Summary Metastasis is the major cause of deaths in cancer. The determinants
enabling metastatic colonization in various organs are an active field in tumor research …

Metastatic disease is the major cause of death from cancer, and immunotherapy and
chemotherapy have had limited success in reversing its progression. Data from mouse …

Metastasis is a complex systemic disease that develops as a result of interactions between
tumor cells and their local and distant microenvironments. Local and systemic immune …

Outgrowths of disseminated metastases remain the primary cause of mortality in cancer
patients; however, molecular and cellular mechanisms regulating metastatic spread remain …

Tumor immune escape and the initiation of metastasis are critical steps in malignant
progression of tumors and have been implicated in the failure of some clinical cancer …

Despite recent therapeutic advances in cancer treatment, metastasis remains the principal
cause of cancer death. Recent work has uncovered the unique biology of metastasis …