Rats were given daily injections of nicotine sulfate in doses ranging from 0.1 to 0.4 mg/kg.
The behavioral effect of these injections was measured as locomotor activity in photocell …

Chronic nicotine treatment generally results in tolerance to several actions of nicotine and a
paradoxical increase in brain nicotinic receptor numbers. Receptor upregulation, it has been …

Repeated exposure to nicotine increases both the number of central nicotinic receptors and
the behavioral stimulant effect of nicotine. In the present experiments, the behavioral …

The effect of acute and chronic (16 days) administration of nicotine on cortical acetylcholine
(ACh) release, gross behaviour and brain nicotinic binding sites was investigated in rats and …

The experiments reported here examined the time course of the development and loss of
tolerance to nicotine as well as the time course for the up-regulation and return to basal …

Nicotine tartrate (2 mg/kg), and a nicotinic agonist, RJR 2403 (1.4 mg/kg), and antagonist,
mecamylamine (1 mg/kg), were administered to separate groups of rats SC twice daily for 10 …

A significant increase in the number of cortical high-affinity (−)-[3 H] nicotine binding sites
was measured in rats treated with nicotine (0.45 mg/kg) twice daily for 18 days. Competition …

The effects of chronic infusion of 3.0 mg/kg/hr of nicotine on the behavioral responses of four
mouse strains (C3H, C57BL, BALB and DBA) to challenge doses of nicotine and on the …

DBA/2 mice were chronically infused with saline (control), 4 mg/kg/hr of nicotine, 4 mg/kg/hr
of mecamylamine or nicotine+ mecamylamine for 7 days. The binding of L-[3H] nicotine was …

Several studies have demonstrated that chronic treatment with nicotine elicits an increase in
the number of brain nicotinic receptors. To determine whether this effect is elicited by other …