FOR THE LAST HALF-CENTURY, RANDOMIZED CLINICAL trials (RCTs) have been the
“gold standard” of evalu-ating the efficacy or effectiveness of clinical interventions …

ABSTRACT BACKGROUND Framing of risk influences the perceptions of treatment benefit.
OBJECTIVE To determine which risk framing format corresponds best to comprehensive …

Background: Meta-analyses of continuous outcomes typically provide enough information
for decision-makers to evaluate the extent to which chance can explain apparent differences …

Objective To perform a systematic review of studies that assessed the potential of patient
decision support interventions (decision aids) to generate savings. Design Systematic …

As hard as it may be for clinicians to adopt new practices, it is often harder for them to “de-
innovate,” or give up old practices, even when new evidence reveals that those practices …

We assessed how much, if anything, people would pay for a laboratory test that predicted
their future disease status. A questionnaire was administered via an internet‐based survey …

BACKGROUND: In 1968, Wilson and Jungner published 10 principles of screening that
often represent the de facto starting point for screening decisions today; 50 years on, are …

Regulatory decisions are often based on multiple clinical end points, but the perspectives
used to judge the relative importance of those end points are predominantly those of expert …

Objective To assess how pressures from patients on doctors in the consultation contribute to
referral and investigation. Design Observational study nested within a randomised …

Regulatory authorities make difficult risk-benefit decisions when approving new drugs. Food
and Drug Administration (FDA) advisory committees and reviewers must consider a complex …