Oligonucleotide-based therapy has experienced remarkable development in the past 2
decades, but its broad applications are severely hampered by delivery vectors. Widely used …

Lipid nanoparticles (LNPs) are currently having an increasing impact on nanomedicines as
delivery agents, among others, of RNA molecules (eg, short interfering RNA for the treatment …

Small interfering RNA (siRNA) molecules have limited transfection efficiency and stability,
necessitating the use of delivery systems to be effective in gene knockdown therapies. In this …

We synthesised silica nanoparticles (SiNP) with covalently linked cationic surface
modifications and demonstrated their ability to electrostatically bind, condense and protect …

A formulation based on a synthetic aminolipid containing a double-tailed with two saturated
alkyl chains along with a non-ionic surfactant polysorbate-80 has been used to form …

Small interfering RNA (siRNA) has been widely used as potential therapeutic for treatment of
various genetic disorders. However, rapid degradation, poor cellular uptake and limited …

Lipid nanoparticles (LNPs) are the most advanced nonviral modality for nucleic acid (NA)
delivery, and have recently gained enormous attention in the fields of RNA therapeutics and …

Ionizable cationic lipids play a critical role in developing new gene therapies for various
biomedical applications, including COVID-19 vaccines. However, it remains unclear whether …

The conjugation of polyethylenimine (PEI) to silica nanoparticles has emerged as a useful
strategy in gene delivery. Here we investigate the influence of the PEI conjugation mode on …

Naked plasmid DNA is a powerful tool for gene therapy, but it is rapidly eliminated from the
circulation after intravenous administration. Therefore, the development of optimized DNA …