This article reports a multidisciplinary approach to produce fluorescently labeled organically
modified silica nanoparticles as a nonviral vector for gene delivery and biophotonics …

Aim: To perform a parallel comparison of key parameters affecting the safety and efficiency
of lipid-based nanovectors (ie, complexing headgroups, composition and preparation …

RNA interference (RNAi) technology has shown great promise for the treatment of cancer
and other genetic disorders. Despite the efforts to increase the target tissue distribution, the …

Abstract Cationic lipid-DNA (CL-DNA) complexes are abundantly used in nonviral gene
therapy clinical applications. Surface functionality is the next step in developing these …

In recent years, with the approval of preventative vaccines for pandemics, lipid nanoparticles
have become a prominent RNA delivery vehicle. The lack of long-lasting effects of non-viral …

Advances in gene therapy have been foreshadowing its potential for the treatment of a vast
range of diseases involving genetic malfunctioning. However, its therapeutic efficiency and …

Synthetic carriers of nucleic acids remain inefficient for practical applications due to their
insufficient functions as compared with viral vectors developed by evolution. Here, a …

Cationic lipids are conceptually and methodologically simple tools to deliver nucleic acids
into the cells. Strategies based on cationic lipids are viable alternatives to viral vectors and …

Mesoporous silica nanoparticles have been synthesized and functionalized with four
different types of molecules containing amino groups, ie, with primary amines only, with …

Among various nanoparticles, the silica nanoparticle (SiNP) is an attractive candidate as a
gene delivery carrier due to advantages such as availability in porous forms for …