Cytochrome P450
FP Guengerich - Enzyme systems that metabolise drugs and …, 2001 - Wiley Online Library
Summary Cytochrome P450 (P450) enzymes are of particular interest because of their
diversity of catalysis of reactions with xenobiotic substrates. The P450s are distributed …
diversity of catalysis of reactions with xenobiotic substrates. The P450s are distributed …
Cytochrome P450 enzymes in drug metabolism and chemical toxicology: An introduction
LL Furge, FP Guengerich - Biochemistry and Molecular Biology …, 2006 - Wiley Online Library
Abstract Cytochrome P450 (P450) enzymes include a family of related enzymes that are
involved in metabolism of vitamins, steroids, fatty acids, and other chemicals. This review …
involved in metabolism of vitamins, steroids, fatty acids, and other chemicals. This review …
Human cytochrome P-450 enzymes
FP Guengerich - Life sciences, 1992 - Elsevier
Abstract Cytochrome P-450 (P-450) enzymes have been studied extensively in experimental
animal models and such is known regarding their structures, regulation, and mechanisms of …
animal models and such is known regarding their structures, regulation, and mechanisms of …
A passion for P450s (remembrances of the early history of research on cytochrome P450)
RW Estabrook - Drug metabolism and disposition, 2003 - ASPET
Many members of the superfamily of hemeproteins, known as cytochrome P450 (P450 or
CYP), are currently described in the literature (over 2000 at the date of this writing)[see …
CYP), are currently described in the literature (over 2000 at the date of this writing)[see …
Cytochrome P450 enzymes
FP Guengerich - Comprehensive Toxicology, Elsevier, Oxford, 2018 - hero.epa.gov
Abstract Cytochrome P450 (P450) enzymes play dominant roles in the metabolism of toxic
chemicals, as well as drugs, steroids, and several other important groups of compounds …
chemicals, as well as drugs, steroids, and several other important groups of compounds …
Cytochrome P450: Significance, reaction mechanisms and active site analogues
WD Woggon - Bioorganic Chemistry: Models and Applications, 2005 - Springer
The significance of cytochrome P450 catalyzed reactions has now been recognized for more
than 30 years [1] as one of nature's most common and sophisticated methods to oxidize …
than 30 years [1] as one of nature's most common and sophisticated methods to oxidize …
Chemical mechanisms of catalysis by cytochromes P-450: a unified view
FP Guengerich, TL Macdonald - Accounts of Chemical Research, 1984 - ACS Publications
Cytochromes P-450 are ubiquitous in nature. The levels of these hemoproteins can be
influenced by many chemicals and the enzymes in turn are capable of me-tabolizing many …
influenced by many chemicals and the enzymes in turn are capable of me-tabolizing many …
Uncommon P450-catalyzed reactions
F Guengerich - Current drug metabolism, 2001 - ingentaconnect.com
Cytochrome P450 (P450) enzymes play major roles in the metabolism of drugs,
carcinogens, steroids, eicosanoids, alkaloids, pesticides, and other important xenobiotics, as …
carcinogens, steroids, eicosanoids, alkaloids, pesticides, and other important xenobiotics, as …
The cytochrome P450 oxidative system
PRO de Montellano - Handbook of Drug Metabolism, Third …, 2019 - taylorfrancis.com
The cytochrome P450 (P450) enzymes are critically involved in the biosynthesis of sterols,
eicosanoids, and other physiologically important substances. The initial work on P450 …
eicosanoids, and other physiologically important substances. The initial work on P450 …
[PDF][PDF] Mechanisms of Cytochrome P450 Reactions.
FP Guengerich, EM Isin - Acta chimica slovenica, 2008 - Citeseer
The cytochrome P450 enzymes (P450s) catalyze a number of different reactions using a
basic chemical template. The course of events follows the order of substrate binding, 1 …
basic chemical template. The course of events follows the order of substrate binding, 1 …