Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been
considered as primarily a disease of the articular cartilage, the participation of subchondral …

Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

Osteoarthritis (OA) is a degenerative joint disease and one of the leading causes of disability
in the United States and across the world. As a disease of the whole joint, OA exhibits a …

There is now general agreement that osteoarthritis (OA) involves all structures in the affected
joint, culminating in the degradation of the articular cartilage. It is appropriate to focus …

The subchondral bone is involved in the pathophysiology of osteoarthritis (OA), both by
biochemical and mechanical pathways. Overloaded OA subchondral bone osteoblasts …

Osteoarthritis (OA) is a major cause of pain and disability in the aging population, but its
pathogenesis remains incompletely understood. Alterations beneath the articular cartilage at …

Osteoarthritis (OA) is a major cause of disability in the adult population. As a progressive
degenerative joint disorder, OA is characterized by cartilage damage, changes in the …

Although cartilage degradation is the characteristic feature of osteoarthritis (OA), it is now
recognized that the whole joint is involved in the progression of OA. In particular, the …

Osteoarthritis is a whole joint disease characterised by the disappearance of the cartilage
associated with subchondral bone sclerosis, formation of osteophytes and a mild …

Osteoarthritis (OA) is considered to be a complex illness in which the tissues of the joint play
a significant role in the initiation and/or progression of the pathophysiology. We still do not …