OBJECTIVE: Osteoarthritis (OA) is the most common form of arthritic disease, and it is a
major cause of disability and impaired quality of life in the elderly. OA is a complex disease …

Subchondral bone remodelling is an integral part of osteoarthritis and involves the
development of subchondral sclerosis seen on plain imaging, along with osteophyte …

Osteoarthritis (OA) is a progressive and disabling disease resulting from a combination of
risk factors, including advancing age, genetics, trauma, knee malalignment, increased …

These findings have an immediate implication for research because new tools need to be
developed to study the subchondral bone–cartilage functional unit. Moreover, it could lead …

This review focuses on recent findings in pathobiology of osteoarthritis (OA). The progress in
this field will be illustrated based on three questions; 1. What factors maintain or alter the …

Arthritis is inflammation of the joints accompanied by osteochondral destruction. It can take
many forms, including osteoarthritis, rheumatoid arthritis, and psoriatic arthritis. These …

Subchondral bone and the synovium play an important role in the initiation and progression
of OA. MRI often permits an early detection of synovial hypertrophy and bone marrow …

The articular surface plays an essential role in load transfer across the joint, and conditions
that produce increased load transfer or altered patterns of load distribution accelerate the …

The extracellular matrix of articular cartilage is the primary target of osteoarthritic cartilage
degradation. However, cartilage cells have a pivotal role during osteoarthritis, as they are …

Over the past few decades, significant progress has been made with respect to new
concepts about the pathogenesis of osteoarthritis (OA). This article summarises some of the …