Objective Previous studies have shown the influence of subchondral bone osteoblasts
(SBOs) on phenotypical changes of articular cartilage chondrocytes (ACCs) during the …

Osteoarthritic subchondral bone is characterized by abnormal bone density and enhanced
production of bone turnover markers, an indication of osteoblast dysfunction. Several studies …

Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the
adult population. OA is primarily caused by trauma induced by an external force or by age …

Osteoarthritis is a painful joint disease characterized by progressive degeneration of the
articular cartilage as well as associated changes to the subchondral bone, synovium, and …

OBJECTIVES: We evaluated the three-dimensional (3D) micro-architecture of subchondral
trabecular (Tb) bone in osteoarthritis (OA). Due to high signal-to-noise ratio and high …

OBJECTIVE: To review the literature on the role and regulation of chondrocyte terminal
differentiation (hypertrophy-like changes) in osteoarthritis (OA) and to integrate this in a …

As the cellular component of articular cartilage, chondrocytes are responsible for
maintaining in a low-turnover state the unique composition and organization of the matrix …

The cellular and molecular mechanisms responsible for the initiation and progression of
osteoarthritis (OA), and in particular cartilage degeneration in OA, are not completely …

Ageing processes play a major contributing role for the development of Osteoarthritis (OA).
This prototypic degenerative condition of ageing is the most common form of arthritis and is …

For many years, pharmaceutical therapies for osteoarthritis (OA) were focused on cartilage.
However, it has been theorized that bone changes such as increased bone volume fraction …