Focal cerebral ischemia activates the nuclear protein poly (ADP-ribose) polymerase (PARP).
Apoptosis-inducing factor (AIF) is a flavoprotein that is normally confined to the …

J. Neurochem.(2010) 113, 1012–1022. Abstract Excessive oxidative damage to DNA leads
to activation of poly (ADP‐ribose) polymerase‐1 (PARP‐1), accumulation of PAR polymers …

Focal cerebral ischemia activates the nuclear protein poly (ADP-ribose) polymerase (PARP)
by single DNA strand breaks which leads to energy depletion and cell necrosis. Deletion or …

Poly (ADP-ribose) polymerase (PARP, EC 2.4. 2.30), an abundant nuclear protein activated
by DNA nicks, mediates cell death in vitro by nicotinamide adenine dinucleotide (NAD) …

Abstract Poly (ADP-ribose) polymerase (PARP)-1 is a DNA nick sensor that transforms ADP-
ribose from βNAD+ in the form of polymer to over 40 nuclear proteins, particularly to …

Poly (ADP-ribose) polymerase-1 (PARP-1) is the guardian of the genome acting as a
sentinel for genomic damage. However, PARP-1 is also mediator of cell death after ischemia …

Poly (ADP-ribose) polymerases (PARPs) are enzymes that are able to catalyze the transfer
of ADP-ribose units from NAD to substrate proteins and are particularly abundant in cell …

The activation of poly (ADP-ribose) polymerase (PARP) in the reperfused brain after
ischemia has been assumed but never has been directly presented. Our studies indicate a …

Excessive activation of poly (ADP‐ribose) polymerase‐1 (PARP‐1) is known to develop
neuronal apoptosis, necrosis and inflammation after ischaemic brain injury. Therefore …

N-[3-(4-Oxo-3, 4-dihydro-phthalazin-1-yl) phenyl]-4-(morpholin-4-yl) butanamide
methanesulfonate monohydrate (ONO-1924H) is a novel inhibitor of poly ADP-ribose …