Time-dependent progression of neurogenic lower urinary tract dysfunction after spinal cord injury in the mouse model

T Saito, D Gotoh, N Wada, P Tyagi… - American Journal …, 2021 - journals.physiology.org
This study evaluated the time-course changes in bladder and external urinary sphincter
(EUS) activity and the expression of mechanosensitive channels in lumbosacral dorsal root …

Sex differences in lower urinary tract function in mice with or without spinal cord injury

M Hashimoto, S Karnup, SL Daugherty… - Neurourology and …, 2024 - Wiley Online Library
Objectives We examined sex differences of lower urinary tract function and molecular
mechanisms in mice with and without spinal cord injury (SCI). Methods SCI was induced by …

Changes in bladder and external urethral sphincter function after spinal cord injury in the rat

MN Kruse, AL Belton… - American Journal of …, 1993 - journals.physiology.org
Spinal cord injury (SCI) in humans results in inappropriate contractions of the external
urethral sphincter muscle (EUS) during micturition (bladder-sphincter dyssynergia), leading …

[HTML][HTML] Current knowledge and novel frontiers in lower urinary tract dysfunction after spinal cord injury: Basic research perspectives

N Wada, S Karnup, K Kadekawa, N Shimizu… - Urological …, 2022 - journals.lww.com
This review article aims to summarize the recent advancement in basic research on lower
urinary tract dysfunction (LUTD) following spinal cord injury (SCI) above the sacral level. We …

Characterization of bladder and external urethral activity in mice with or without spinal cord injury—a comparison study with rats

K Kadekawa, N Yoshimura, T Majima… - American Journal …, 2016 - journals.physiology.org
To clarify the lower urinary tract function in mice, we compared bladder and urethral activity
between rats and mice with or without spinal cord injury (SCI). Female Sprague-Dawley rats …

Molecular characterization of non-neurogenic and neurogenic lower urinary tract dysfunction (LUTD) in SCI-induced and partial bladder outlet obstruction mouse …

M von Siebenthal, A Akshay, M Besic… - International journal of …, 2023 - mdpi.com
We examined bladder function following spinal cord injury (SCI) by repeated urodynamic
investigation (UDI), including external urethral sphincter (EUS) electromyography (EMG) in …

Assessing neurogenic lower urinary tract dysfunction after spinal cord injury: Animal models in preclinical neuro-urology research

AW Doelman, F Streijger, SJA Majerus, MS Damaser… - Biomedicines, 2023 - mdpi.com
Neurogenic bladder dysfunction is a condition that affects both bladder storage and voiding
function and remains one of the leading causes of morbidity after spinal cord injury (SCI) …

[HTML][HTML] Slow development of bladder malfunction parallels spinal cord fiber sprouting and interneurons' loss after spinal cord transection

AM Sartori, AS Hofer, MI Scheuber, R Rust… - Experimental …, 2022 - Elsevier
Neurogenic lower urinary tract dysfunction typically develops after spinal cord injury. We
investigated the time course and the anatomical changes in the spinal cord that may be …

Post‐injury bladder management strategy influences lower urinary tract dysfunction in the mouse model of spinal cord injury

N Wada, T Shimizu, S Takai, N Shimizu… - Neurourology and …, 2017 - Wiley Online Library
Aims To examine the effects of a different number of daily bladder squeezes on bladder
dysfunction in mice with spinal cord injury (SCI). Methods Spinal cord was transected at the …

Influence of spinal cord injury on the morphology of bladder afferent and efferent neurons

MN Kruse, LA Bray, WC De Groat - Journal of the autonomic nervous …, 1995 - Elsevier
Severe micturition dysfunction can occur following spinal cord injury (SCI) due to abnormal
contractions of the urethral sphincter during bladder contractions (bladder/sphincter …