Background The aim of this study was to clarify the significance of subchondral bone in the
pathology of osteoarthritis (OA) by investigating the expression of inflammatory cyto-kines …

Objective: The aim of this study was to investigate the expression of several cytokines, matrix
metalloproteinases (MMPs), and tissue inhibitor of matrix metalloproteinases (TIMP)-1 in …

As a main cause of morbidity in the aged population, osteoarthritis (OA) is characterized by
cartilage destruction, synovium inflammation, osteophytes, and subchondral bone sclerosis …

Objective The differentiation of mesenchymal stem cells (MSCs) into chondrocytes provides
an attractive basis for the repair and regeneration of articular cartilage. Under clinical …

This study aimed to investigate the additional effect of ovariectomy-induced osteoporosis
(OP) on the pathology of knee osteoarthritis (OA) in a rat meniscectomized model …

Introduction Osteoporosis (OP) increases cartilage damage in a combined rabbit model of
OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at …

Objective The receptor activator of nuclear factor κB (RANK) is a member of the tumor
necrosis factor receptor family. It is activated by the secreted or cell surface–bound RANK …

Objectives. To investigate the importance of activation of the transcription factor, nuclear
factor-κB (NF-κB) by interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) in the …

Articular chondrocytes maintain cartilage matrix turnover and have the capacity for anabolic
and catabolic activities that can be influenced by injury and disease. This study tested the …

Objective To identify the genes up‐regulated by interleukin‐1 (IL‐1) in combination with
oncostatin M (OSM) in chondrocytes that may be involved in mechanisms of cartilage repair …