The features of impaired permeability of endothelium and increased pinocytosis of
endothelial cells in developing experimental atherosclerosis in rabbits are described on the …

It has been shown in experiments on endothelial cells in culture that despite the active
uptake of mLDL (acetylated) by scavenger receptors, cholesterol and its esters do not …

In atherosclerosis, macrophages are important for intracellular lipid accumulation and foam
cell formation. Monocytes respond to chemotactic factors, cytokines, and macrophage …

Modern techniques of investigation have revealed several similarities between
atherosclerosis and chronic inflammation, and that immune mechanisms seem to operate in …

To elucidate the role of macrophages in atherosclerosis, sequential observations were
carried out on cholesterol-induced aortic lesions of the rabbit with the immunoperoxidase …

The formation of macrophage foam cells is in the early stage of the development of
atherosclerosis. The transformation of macrophage foam cell involves the disruption of a …

Atherogenesis is a disorder of the artery wall that involves: adhesion of monocytes and
lymphocytes to the endothelial cell surface; migration of monocytes into the sub-endothelial …

Context.—Inflammation is pivotal to atherosclerosis. The monocyte-macrophage, a crucial
cell in atherogenesis, is present during all stages of atherosclerosis. However, there is a …

Atherosclerosis is now recognized as a multifactorial disease process in which a number of
distinct but overlapping pathways of pathogenesis are involved. The principal cell types of …

In the article are given the facts, which confirm and which develop the main position of the
immunoinflammatory concept of atherosclerosis pathogenesis. As leading …