Amiodarone (AM) is a potent antidysrhythmic agent which can cause potentially
lifethreatening pulmonary fibrosis, and N-desethylamiodarone (DEA) is a metabolite of AM …

Amiodarone (AM) is a potent antidysrhythmic agent that can cause potentially life-
threatening pulmonary fibrosis, and N-desethylamiodarone (DEA), an AM metabolite, may …

The antiarrhythmic amiodarone (AM) and its metabolite desethylamiodarone (Des) are
known to cause AM-induced pulmonary toxicity, but the mechanisms underlying this …

The potent and efficacious anti-dysrhythmic agent amiodarone (AM) can cause potentially
life-threatening lung damage (amiodarone-induced pulmonary toxicity; AIPT), which is …

Conclusions Since the discovery of amiodarone over 30 years ago, the mechanisms
underlying serious adverse effects remain to be resolved and still limit drug usefulness …

Amiodarone (AM), a drug used in the treatment of cardiac dysrrhythmias, can produce
severe pulmonary adverse effects, including fibrosis. Although the pathogenesis of AM …

Amiodarone (AM) is a potent and efficacious antidysrhythmic agent that can cause
potentially life-threatening pulmonary fibrosis. Vitamin E has been demonstrated to …

Context: Amiodarone (an iodinated benzofuran) is a Class III antiarrhythmic drug that
produces significant pulmonary disease. Proposed mechanisms of this cytotoxicity include …

Amiodarone (AM), a potent antidysrhythmic agent, can cause potentially life-threatening
pulmonary fibrosis. In the present investigation of mechanisms of initiation of AM lung …

Amiodarone-induced pulmonary toxicity is a serious side-effect, but the underlying
molecular mechanisms remain unclear. We examined phospholipidosis and apoptosis in rat …