Amiodarone is a potent antidysrhythmic drug that is associated with severe pulmonary
toxicity. The mechanism of amiodarone pulmonary toxicity is poorly understood. To …

Associated with amiodarone (AM) therapy is pneumonitis, which may progress to life-
threatening pulmonary fibrosis. Although the etiology of amiodarone-induced pulmonary …

Amiodarone (AD) is gaining support as a first-line antiarrhythmic drug despite its potentially
fatal pulmonary toxicity involving inflammation and fibrosis. The goals of this study were to …

To determine whether a hypersensitivity reaction played a role in amiodarone-induced
pulmonary inflammation and affected humoral immunity, we examined pulmonary …

Amiodarone (AD) has been shown to produce a transient pulmonary fibrosis in hamsters
after intratracheal (it) instillation. The goal of this study was to examine bronchoalveolar …

Although amiodarone is a highly efficacious antidysrhythmic agent, the drug produces
numerous adverse effects. The most critical of these is pulmonary toxicity because of the …

A rat model of amiodarone-induced pulmonary toxicity is described. The rats were fed, by
gavage, 175 mg/kg/day of amiodarone hydrochloride suspended in methyl cellulose …

Intratracheal instillation of the antiarrhythmic drug amiodarone (AD) in hamsters is an
established animal model of AD-induced pulmonary fibrosis. A metabolite of AD …

In previous studies, we showed that Fischer rats fed 175 mg/kg of amiodarone accumulated
large amounts of drug and metabolite in the lung and developed pulmonary toxicity …

Amiodarone is a potent antiarrhythmic agent with a number of side-effects, the most serious
being the development of pulmonary toxicity. The purpose of the study was to determine if a …