Objective This study was undertaken to investigate the effect of long-term amiodarone
administration and withdrawal on the histological structure of rat lung. In addition, the …

This study was designed to specify the toxicity of amiodarone toward mouse pulmonary
endothelial cells in comparison with that of another cationic amphiphilic drug, ie, mianserin …

Treatment of humans with the antiarrhythmic drug amiodarone can cause pulmonary
pathology and toxicity. The disorder is associated with the accumulation of phospholipid …

Amiodarone, an antiarrhythmic drug toxic toward the lung, is metabolized through sequential
modifications of the diethylaminoethoxy group to mono-N-desethylamiodarone (MDEA), di-N …

Amiodarone is an effective antidysrhythmic agent, restricted in use by the development of
pulmonary toxicity. Several in vivo animal models have been used to study amiodarone …

Amiodarone (ADR), a new antiarrhythmic drug for life-threatening cardiac arrhythmias,
causes pneumonitis or lung fibrosis in a sizeable minority of patients. The cause of lung …

Amiodarone‐(AM‐) induced pulmonary toxicity (AIPT) is still a matter of research and is
poorly understood. In attempting to resolve this issue, we treated Sprague‐Dawley rats with …

Treatment of humans with the antiarrhythmic drug, amiodarone (AD), may result in the
development of pulmonary toxicity. To characterize this response, male Fischer 344 rats …

Amiodarone, a cardiac antiarrhythmic agent, has been associated with the development of
interstitial pulmonary fibrosis in patients receiving prolonged therapy with the drug. To …

We read with interest the article by Ide et al. 1 The authors showed that amiodarone protects
cardiac myocytes against injury mediated by oxidative stress, and they conclude that this …