Amiodarone may induce lung damage by direct toxicity or indirectly through inflammation.
To clarify the mechanism of direct toxicity, we briefly exposed rabbit alveolar macrophages …

Administration of amiodarone, although often lifesaving, is associated with pulmonary side
effects. Patients with amiodarone pulmonary toxicity can present with either a chronic …

Pulmonary toxicity, including fibrosis, is a serious adverse effect associated with the
antidysrhythmic drug amiodarone (AM). We tested the potential usefulness of pirfenidone …

Amiodarone is one of the most effective anti-arrhythmic drugs available. However, its use is
often limited by potentially life-threatening toxicities, including hepatotoxicity and pulmonary …

BACKGROUND: Amiodarone (AMD) is a strong antiarrhythmic drug but has severe side
effects such as pulmonary toxicity. There are no indicators or drugs that can prevent the …

Amiodarone (AM) is an antidysrhythmic agent with a propensity to cause pulmonary toxicity,
including potentially fatal fibrosis. In the present study, the potential roles of c-Jun and …

To investigate whether amiodarone induces apoptosis in cells of the L-132 human lung
epithelial cell line, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay …

Amiodarone, a bi-iodinated benzofuran derivative, is, because of its high effectiveness, one
of the most widely used antiarrhythmic agents. However, adverse effects, especially …

The use of the antiarrythmic drug amiodarone (AD) has been limited by the propensity of the
drug to cause severe lung damage. AD has been shown to produce a transient pulmonary …

As damage to the pulmonary vascular endothelium may be responsible for the lung toxicity
of amiodarone, we evaluated the cytolytic toxicity of the drug in cultures of endothelial cells …