Increasing the flux through central carbon metabolism is difficult because of rigidity in
regulatory structures, at both the genetic and the enzymatic levels. Here we describe …

The GAL promoters are applied in metabolic engineering and synthetic biology to control
gene expression in the budding yeast Saccharomyces cerevisiae. In gal80Δ background …

The role of the proteins encoded by the GAL80 gene, the MIG1 gene and the GAL6 gene in
glucose control of galactose consumption by Saccharomyces cerevisiae was studied by …

Through genome-wide transcript analysis of a reference strain and two recombinant
Saccharomyces cerevisiae strains with different rates of galactose uptake, we obtained …

Despite their close phylogenetic relationship, Kluyveromyces lactis and Saccharomyces
cerevisiae have adapted their carbon utilization systems to different environments. Although …

Identification of the underlying molecular mechanisms for a derived phenotype by adaptive
evolution is difficult. Here, we performed a systems-level inquiry into the metabolic changes …

Although Saccharomyces cerevisiae is capable of fermenting galactose into ethanol,
ethanol yield and productivity from galactose are significantly lower than those from glucose …

Engineering control of metabolic pathways is important to improving product titers and
yields. Traditional methods such as overexpressing pathway enzymes and deleting …

The Leloir galactose utilization or GAL pathway of budding yeasts, including that of the
baker's yeast Saccharomyces cerevisiae and the opportunistic human pathogen Candida …

Glucose is the favoured carbon source for Saccharomyces cerevisiae, and the Leloir
pathway for galactose utilization is only induced in the presence of galactose during glucose …