LAT (linker for activation of T cells) is a transmembrane adaptor protein that plays an
essential role in TCR-mediated signaling and thymocyte development. Because LAT …

LAT (linker for activation of T cells) is an integral membrane adaptor protein that constitutes
in T cells a major substrate of the ZAP‐70 protein tyrosine kinase. LAT coordinates the …

Linker for activation of T cells (LAT) is a membrane-associated adaptor protein that is
phosphorylated on multiple tyrosines upon TCR cross-linking. Previous studies show that …

The linker molecule LAT is a substrate of the tyrosine kinases activated following TCR
engagement. Phosphorylated LAT binds many critical signaling molecules. The central role …

The linker for activation of T cells (LAT) is an adaptor protein that couples TCR engagement
to downstream signaling cascades. LAT is important in early thymocyte development as LAT …

The adaptor molecule LAT (l inker for a ctivation of T cells) is a palmitoylated integral
membrane protein that localizes to the glycolipid-enriched microdomains in the plasma …

Engagement of the T cell receptor for antigen (TCR) induces formation of signaling
complexes mediated through the transmembrane adaptor protein, the linker for activation of …

Despite compromised T cell antigen receptor (TCR) signaling, mice in which tyrosine 136 of
the adaptor linker for activation of T cells (LAT) was constitutively mutated (Lat Y136F mice) …

Current evidences indicate that T cells use protein sorting and degradation to control
duration and specificity of T cell receptor (TcR) signalling, including the CD3ζ chain which is …

LAT (linker for activation of T cells) is essential for T cell receptor signaling. Mice
homozygous for a mutation of the three C-terminal LAT tyrosine residues showed a block in …